Seroatlas · Human Serome Atlas

LIMA1

LIM domain and actin-binding protein 1

Also known as: EPLIN, LIMA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHB6
Gene
LIMA1
Ensembl
ENSG00000050405
Chromosome
12
Canonical length
759 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Focal adhesion sites,Cytosol

OverviewNCBI Gene

This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

759 residues, UniProt reviewed canonical sequence.

>Q9UHB6|LIMA1
     1  MESSPFNRRQ WTSLSLRVTA KELSLVNKNK SSAIVEIFSK YQKAAEETNM EKKRSNTENL
    61  SQHFRKGTLT VLKKKWENPG LGAESHTDSL RNSSTEIRHR ADHPPAEVTS HAASGAKADQ
   121  EEQIHPRSRL RSPPEALVQG RYPHIKDGED LKDHSTESKK MENCLGESRH EVEKSEISEN
   181  TDASGKIEKY NVPLNRLKMM FEKGEPTQTK ILRAQSRSAS GRKISENSYS LDDLEIGPGQ
   241  LSSSTFDSEK NESRRNLELP RLSETSIKDR MAKYQAAVSK QSSSTNYTNE LKASGGEIKI
   301  HKMEQKENVP PGPEVCITHQ EGEKISANEN SLAVRSTPAE DDSRDSQVKS EVQQPVHPKP
   361  LSPDSRASSL SESSPPKAMK KFQAPARETC VECQKTVYPM ERLLANQQVF HISCFRCSYC
   421  NNKLSLGTYA SLHGRIYCKP HFNQLFKSKG NYDEGFGHRP HKDLWASKNE NEEILERPAQ
   481  LANARETPHS PGVEDAPIAK VGVLAASMEA KASSQQEKED KPAETKKLRI AWPPPTELGS
   541  SGSALEEGIK MSKPKWPPED EISKPEVPED VDLDLKKLRR SSSLKERSRP FTVAASFQST
   601  SVKSPKTVSP PIRKGWSMSE QSEESVGGRV AERKQVENAK ASKKNGNVGK TTWQNKESKG
   661  ETGKRSKEGH SLEMENENLV ENGADSDEDD NSFLKQQSPQ EPKSLNWSSF VDNTFAEEFT
   721  TQNQKSQDVE LWEGEVVKEL SVEEQIKRNR YYDEDEDEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIMA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
123 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 123 nTPM
  • colon: 117 nTPM
  • adipose tissue: 117 nTPM
  • small intestine: 115 nTPM
  • duodenum: 106 nTPM
  • stomach: 91 nTPM

Single-cell type

  • adipocytes: 906 nCPM
  • extravillous trophoblasts: 864 nCPM
  • epididymal basal cells: 736 nCPM
  • basal keratinocytes: 651 nCPM
  • colonocytes: 627 nCPM
  • urothelial cells: 617 nCPM

Immune cell

  • T-reg: 15 nTPM
  • memory CD4 T-cell: 8.3 nTPM
  • memory CD8 T-cell: 8.1 nTPM
  • gdT-cell: 6.6 nTPM
  • naive CD8 T-cell: 6.1 nTPM
  • NK-cell: 6 nTPM

Brain region

  • cerebellum: 71 nTPM
  • pons: 23 nTPM
  • white matter: 20 nTPM
  • medulla oblongata: 18 nTPM
  • basal ganglia: 15 nTPM
  • spinal cord: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
1.51
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIMA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIMA1 as an antibody target. Whether an autoantibody or antibody against LIMA1 could matter depends on whether native LIMA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIMA1 is annotated at the cell surface, where native LIMA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LIMA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIMA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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