Seroatlas · Human Serome Atlas

LAIR1

Leukocyte-associated immunoglobulin-like receptor 1

Also known as: CD305, LAIR-1, LAIR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6GTX8
Gene
LAIR1
Ensembl
ENSG00000167613
Chromosome
19
Canonical length
287 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q6GTX8|LAIR1
     1  MSPHPTALLG LVLCLAQTIH TQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL
    61  ERDSRSTYND TEDVSQASPS ESEARFRIDS VREGNAGLYR CIYYKPPKWS EQSDYLELLV
   121  KESSGGPDSP DTEPGSSAGP TQRPSDNSHN EHAPASQGLK AEHLYILIGV SVVFLFCLLL
   181  LVLFCLHRQN QIKQGPPRSK DEEQKPQQRP DLAVDVLERT ADKATVNGLP EKDRETDTSA
   241  LAAGSSQEVT YAQLDHWALT QRTARAVSPQ STKPMAESIT YAAVARH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAIR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 45 nTPM
  • lung: 27 nTPM
  • adipose tissue: 23 nTPM
  • spinal cord: 17 nTPM
  • blood vessel: 15 nTPM
  • small intestine: 13 nTPM

Single-cell type

  • microglia: 85 nCPM
  • macrophages: 16 nCPM
  • mast cells: 11 nCPM
  • thymocytes: 10 nCPM
  • monocytes: 9.3 nCPM
  • nk-cells: 8.7 nCPM

Immune cell

  • basophil: 13 nTPM
  • eosinophil: 12 nTPM
  • plasmacytoid DC: 11 nTPM
  • non-classical monocyte: 11 nTPM
  • intermediate monocyte: 9.8 nTPM
  • gdT-cell: 7.7 nTPM

Brain region

  • cerebellum: 4.7 nTPM
  • medulla oblongata: 4.1 nTPM
  • thalamus: 4 nTPM
  • pons: 3.7 nTPM
  • white matter: 3.6 nTPM
  • cerebral cortex: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
-0.31
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAIR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAIR1 as an antibody target. Whether an autoantibody or antibody against LAIR1 could matter depends on whether native LAIR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAIR1 is annotated at the cell surface, where native LAIR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LAIR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LAIR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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