Seroatlas · Human Serome Atlas

FCRL6

Fc receptor-like protein 6

Also known as: FcRH6, FCRL6_HUMAN, FLJ16056, IFGP6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6DN72
Gene: FCRL6
Ensembl: ENSG00000181036
Chromosome: 1
Canonical length: 434 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables MHC class II protein binding activity and protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q6DN72|FCRL6
     1  MLLWTAVLLF VPCVGKTVWL YLQAWPNPVF EGDALTLRCQ GWKNTPLSQV KFYRDGKFLH
    61  FSKENQTLSM GAATVQSRGQ YSCSGQVMYI PQTFTQTSET AMVQVQELFP PPVLSAIPSP
   121  EPREGSLVTL RCQTKLHPLR SALRLLFSFH KDGHTLQDRG PHPELCIPGA KEGDSGLYWC
   181  EVAPEGGQVQ KQSPQLEVRV QAPVSRPVLT LHHGPADPAV GDMVQLLCEA QRGSPPILYS
   241  FYLDEKIVGN HSAPCGGTTS LLFPVKSEQD AGNYSCEAEN SVSRERSEPK KLSLKGSQVL
   301  FTPASNWLVP WLPASLLGLM VIAAALLVYV RSWRKAGPLP SQIPPTAPGG EQCPLYANVH
   361  HQKGKDEGVV YSVVHRTSKR SEARSAEFTV GRKDSSIICA EVRCLQPSEV SSTEVNMRSR
   421  TLQEPLSDCE EVLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCRL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

spleen: 12 nTPM
bone marrow: 7.4 nTPM
lung: 5.4 nTPM
lymph node: 5.4 nTPM
liver: 3.1 nTPM
epididymis: 2.2 nTPM

Single-cell type

nk-cells: 81 nCPM
t-cells: 36 nCPM
cdc: 6.9 nCPM
gastric chief cells: 4.4 nCPM
kupffer cells: 3.1 nCPM
pdcs: 3.1 nCPM

Immune cell

gdT-cell: 143 nTPM
memory CD8 T-cell: 134 nTPM
naive CD8 T-cell: 103 nTPM
total PBMC: 54 nTPM
NK-cell: 52 nTPM
memory CD4 T-cell: 26 nTPM

Brain region

medulla oblongata: 2.3 nTPM
white matter: 2.2 nTPM
pons: 1.9 nTPM
thalamus: 1.8 nTPM
cerebellum: 1.7 nTPM
cerebral cortex: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: -1.55
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FCRL6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCRL6 as an antibody target. Whether an autoantibody or antibody against FCRL6 could matter depends on whether native FCRL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCRL6 is annotated at the cell surface, where native FCRL6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FCRL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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