FLT1

Protein identityUniProt · HPA

UniProt accession

P17948

Gene

FLT1

Ensembl

ENSG00000102755

Chromosome

13

Canonical length

1338 aa

Protein class

Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins

Subcellular location

Plasma membrane,Actin filaments,Cytosol

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

1338 residues, UniProt reviewed canonical sequence.

>P17948|FLT1
     1  MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ HIMQAGQTLH LQCRGEAAHK
    61  WSLPEMVSKE SERLSITKSA CGRNGKQFCS TLTLNTAQAN HTGFYSCKYL AVPTSKKKET
   121  ESAIYIFISD TGRPFVEMYS EIPEIIHMTE GRELVIPCRV TSPNITVTLK KFPLDTLIPD
   181  GKRIIWDSRK GFIISNATYK EIGLLTCEAT VNGHLYKTNY LTHRQTNTII DVQISTPRPV
   241  KLLRGHTLVL NCTATTPLNT RVQMTWSYPD EKNKRASVRR RIDQSNSHAN IFYSVLTIDK
   301  MQNKDKGLYT CRVRSGPSFK SVNTSVHIYD KAFITVKHRK QQVLETVAGK RSYRLSMKVK
   361  AFPSPEVVWL KDGLPATEKS ARYLTRGYSL IIKDVTEEDA GNYTILLSIK QSNVFKNLTA
   421  TLIVNVKPQI YEKAVSSFPD PALYPLGSRQ ILTCTAYGIP QPTIKWFWHP CNHNHSEARC
   481  DFCSNNEESF ILDADSNMGN RIESITQRMA IIEGKNKMAS TLVVADSRIS GIYICIASNK
   541  VGTVGRNISF YITDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDVTWI LLRTVNNRTM
   601  HYSISKQKMA ITKEHSITLN LTIMNVSLQD SGTYACRARN VYTGEEILQK KEITIRDQEA
   661  PYLLRNLSDH TVAISSSTTL DCHANGVPEP QITWFKNNHK IQQEPGIILG PGSSTLFIER
   721  VTEEDEGVYH CKATNQKGSV ESSAYLTVQG TSDKSNLELI TLTCTCVAAT LFWLLLTLFI
   781  RKMKRSSSEI KTDYLSIIMD PDEVPLDEQC ERLPYDASKW EFARERLKLG KSLGRGAFGK
   841  VVQASAFGIK KSPTCRTVAV KMLKEGATAS EYKALMTELK ILTHIGHHLN VVNLLGACTK
   901  QGGPLMVIVE YCKYGNLSNY LKSKRDLFFL NKDAALHMEP KKEKMEPGLE QGKKPRLDSV
   961  TSSESFASSG FQEDKSLSDV EEEEDSDGFY KEPITMEDLI SYSFQVARGM EFLSSRKCIH
  1021  RDLAARNILL SENNVVKICD FGLARDIYKN PDYVRKGDTR LPLKWMAPES IFDKIYSTKS
  1081  DVWSYGVLLW EIFSLGGSPY PGVQMDEDFC SRLREGMRMR APEYSTPEIY QIMLDCWHRD
  1141  PKERPRFAEL VEKLGDLLQA NVQQDGKDYI PINAILTGNS GFTYSTPAFS EDFFKESISA
  1201  PKFNSGSSDD VRYVNAFKFM SLERIKTFEE LLPNATSMFD DYQGDSSTLL ASPMLKRFTW
  1261  TDSKPKASLK IDLRVTSKSK ESGLSDVSRP SFCHSSCGHV SEGKRRFTYD HAELERKIAC
  1321  CSPPPDYNSV VLYSTPPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

394 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FLT1.

Disease | ImmuneIEDB

Conditions an epitope on FLT1 was assayed in.

• renal cell carcinoma T cell
• high grade glioma T cell
• cervical cancer T cell
• brain glioma T cell
• gastric adenocarcinoma T cell
• pancreatic adenocarcinoma T cell
• esophagus squamous cell carcinoma T cell
• lung non-small cell carcinoma T cell
• cholangiocarcinoma T cell
• colorectal cancer T cell

ReferencesPubMed · IEDB

Publications for FLT1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

gnomAD missense Z

1.45

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• blood vessel morphogenesis
• cell differentiation
• cell migration
• cell surface receptor protein tyrosine kinase signaling pathway
• cellular response to vascular endothelial growth factor stimulus
• embryonic morphogenesis
• hyaloid vascular plexus regression
• monocyte chemotaxis
• negative regulation of vascular endothelial cell proliferation
• peptidyl-tyrosine phosphorylation
• positive regulation of angiogenesis
• positive regulation of cell migration
• positive regulation of cell population proliferation
• positive regulation of MAP kinase activity
• positive regulation of MAPK cascade
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• protein autophosphorylation
• sprouting angiogenesis
• vascular endothelial growth factor receptor signaling pathway
• vascular endothelial growth factor receptor-1 signaling pathway

Molecular functions

• ATP binding
• growth factor binding
• transmembrane receptor protein tyrosine kinase activity
• vascular endothelial growth factor receptor activity
• placental growth factor receptor activity

Cellular components

• actin cytoskeleton
• cytosol
• endosome
• extracellular space
• focal adhesion
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• Tyrosine-protein kinase, receptor class III, conserved site
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Tyrosine-protein kinase, active site
• Protein kinase-like domain superfamily
• Immunoglobulin I-set
• Immunoglobulin V-set domain
• Immunoglobulin-like beta-sandwich domain
• Immunoglobulin-like fold
• Protein kinase, ATP binding site
• Tyrosine-protein kinase, catalytic domain
• Immunoglobulin-like domain superfamily
• VEGFR-2, transmembrane domain
• Receptor Tyrosine Kinase
• VEGFR1-3, fifth immunoglobulin-like domain
• VEGFR1-3-like, N-terminal Ig-like domain
• Immunoglobulin domain
• Immunoglobulin I-set domain
• Protein tyrosine and serine/threonine kinase
• Immunoglobulin domain
• VEGFR-2 Transmembrane domain
• Vascular endothelial growth factor receptor 1-like, Ig-like domain
• VEGFR1-3, N-terminal Ig-like domain
• VEGFR-1-like, immunoglobulin-like domain
• Vascular endothelial growth factor receptor 1 (VEGFR1)

KeywordsUniProt

• Angiogenesis
• ATP-binding
• Cell membrane
• Chemotaxis
• Cytoplasm
• Developmental protein
• Differentiation
• Disulfide bond
• Endosome
• Glycoprotein
• Immunoglobulin domain
• Kinase
• Membrane
• Nucleotide-binding
• Phosphoprotein
• Receptor
• Repeat
• Secreted
• Signal
• Transferase
• Transmembrane
• Transmembrane helix
• Tyrosine-protein kinase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of FLT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PGF
• PTPRB
• RACK1
• VEGFA
• VEGFB
• CBL
• PLCG1
• PTPN11
• GRB2
• NCK1
• CRK
• PIK3R2
• CRKL
• PIK3R1