Seroatlas · Human Serome Atlas

CD84

SLAM family member 5

Also known as: hCD84, mCD84, SLAF5_HUMAN, SLAMF5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UIB8
Gene
CD84
Ensembl
ENSG00000066294
Chromosome
1
Canonical length
345 aa
Protein class
CD markers, Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q9UIB8|CD84
     1  MAQHHLWILL LCLQTWPEAA GKDSEIFTVN GILGESVTFP VNIQEPRQVK IIAWTSKTSV
    61  AYVTPGDSET APVVTVTHRN YYERIHALGP NYNLVISDLR MEDAGDYKAD INTQADPYTT
   121  TKRYNLQIYR RLGKPKITQS LMASVNSTCN VTLTCSVEKE EKNVTYNWSP LGEEGNVLQI
   181  FQTPEDQELT YTCTAQNPVS NNSDSISARQ LCADIAMGFR THHTGLLSVL AMFFLLVLIL
   241  SSVFLFRLFK RRQGRIFPEG SCLNTFTKNP YAASKKTIYT YIMASRNTQP AESRIYDEIL
   301  QSKVLPSKEE PVNTVYSEVQ FADKMGKAST QDSKPPGTSS YEIVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD84 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 23 nTPM
  • appendix: 18 nTPM
  • spleen: 14 nTPM
  • tonsil: 12 nTPM
  • thymus: 9.2 nTPM
  • bone marrow: 7.5 nTPM

Single-cell type

  • kupffer cells: 362 nCPM
  • mast cells: 210 nCPM
  • microglia: 180 nCPM
  • platelets: 179 nCPM
  • macrophages: 166 nCPM
  • megakaryocyte progenitors: 135 nCPM

Immune cell

  • basophil: 33 nTPM
  • eosinophil: 15 nTPM
  • T-reg: 11 nTPM
  • memory CD8 T-cell: 10 nTPM
  • classical monocyte: 9.6 nTPM
  • total PBMC: 8.8 nTPM

Brain region

  • white matter: 17 nTPM
  • thalamus: 12 nTPM
  • medulla oblongata: 12 nTPM
  • spinal cord: 9.7 nTPM
  • pons: 9 nTPM
  • midbrain: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.32
gnomAD pLI
0
gnomAD missense Z
0.22
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD84 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD84 as an antibody target. Whether an autoantibody or antibody against CD84 could matter depends on whether native CD84 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD84 is annotated at the cell surface, where native CD84 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD84 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD84. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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