Seroatlas · Human Serome Atlas

FGFR2

Fibroblast growth factor receptor 2

Also known as: BEK, CD332, CEK3, CFD1, ECT1, FGFR2_HUMAN, JWS, K-SAM, KGFR, TK14, TK25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P21802
Gene
FGFR2
Ensembl
ENSG00000066468
Chromosome
10
Canonical length
821 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Vesicles,Cell Junctions
Secretome location
Secreted - unknown location
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

821 residues, UniProt reviewed canonical sequence.

>P21802|FGFR2
     1  MVSWGRFICL VVVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEVY VAAPGESLEV
    61  RCLLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR DSGLYACTAS RTVDSETWYF
   121  MVNVTDAISS GDDEDDTDGA EDFVSENSNN KRAPYWTNTE KMEKRLHAVP AANTVKFRCP
   181  AGGNPMPTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CVVENEYGSI
   241  NHTYHLDVVE RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK
   301  YGPDGLPYLK VLKAAGVNTT DKEIEVLYIR NVTFEDAGEY TCLAGNSIGI SFHSAWLTVL
   361  PAPGREKEIT ASPDYLEIAI YCIGVFLIAC MVVTVILCRM KNTTKKPDFS SQPAVHKLTK
   421  RIPLRRQVTV SAESSSSMNS NTPLVRITTR LSSTADTPML AGVSEYELPE DPKWEFPRDK
   481  LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM
   541  IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF
   601  KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT
   661  TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH
   721  RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDLDRI LTLTTNEEYL DLSQPLEQYS
   781  PSYPDTRSSC SSGDDSVFSP DPMPYEPCLP QYPHINGSVK T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGFR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
549 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 549 nTPM
  • midbrain: 162 nTPM
  • choroid plexus: 102 nTPM
  • hippocampal formation: 77 nTPM
  • basal ganglia: 59 nTPM
  • hypothalamus: 50 nTPM

Single-cell type

  • choroid plexus epithelial cells: 1,987 nCPM
  • bergmann glia: 1,332 nCPM
  • gastric progenitor cells: 856 nCPM
  • cholangiocytes: 631 nCPM
  • oligodendrocytes: 629 nCPM
  • pituitary stem cells: 272 nCPM

Immune cell

  • basophil: 3 nTPM
  • eosinophil: 2 nTPM
  • neutrophil: 0.3 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • white matter: 453 nTPM
  • medulla oblongata: 395 nTPM
  • midbrain: 262 nTPM
  • choroid plexus: 256 nTPM
  • basal ganglia: 256 nTPM
  • cerebellum: 255 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGFR2.

Disease | AllUniProt

Conditions FGFR2 is implicated in, by any mechanism.

Disease | GeneticClinVar

130 pathogenic / likely-pathogenic of 950 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
2.4
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGFR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGFR2 as an antibody target. Whether an autoantibody or antibody against FGFR2 could matter depends on whether native FGFR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGFR2 is annotated at the cell surface, where native FGFR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FGFR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGFR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...