Seroatlas · Human Serome Atlas

MILR1

Allergin-1

Also known as: Allergin-1, C17orf60, MCA-32, MILR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6M3
Gene: MILR1
Ensembl: ENSG00000271605
Chromosome: 17
Canonical length: 343 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway; mast cell degranulation; and negative regulation of mast cell activation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q7Z6M3|MILR1
     1  MWSHLNRLLF WSIFSSVTCR KAVLDCEAMK TNEFPSPCLD SKTKVVMKGQ NVSMFCSHKN
    61  KSLQITYSLF RRKTHLGTQD GKGEPAIFNL SITEAHESGP YKCKAQVTSC SKYSRDFSFT
   121  IVDPVTSPVL NIMVIQTETD RHITLHCLSV NGSLPINYTF FENHVAISPA ISKYDREPAE
   181  FNLTKKNPGE EEEYRCEAKN RLPNYATYSH PVTMPSTGGD SCPFCLKLLL PGLLLLLVVI
   241  ILILAFWVLP KYKTRKAMRN NVPRDRGDTA MEVGIYANIL EKQAKEESVP EVGSRPCVST
   301  AQDEAKHSQE LQYATPVFQE VAPREQEACD SYKSGYVYSE LNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MILR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

appendix: 24 nTPM
lymph node: 23 nTPM
tonsil: 20 nTPM
bone marrow: 17 nTPM
spleen: 16 nTPM
placenta: 15 nTPM

Single-cell type

hofbauer cells: 145 nCPM
epicardial cells: 102 nCPM
microglia: 77 nCPM
pdcs: 51 nCPM
kupffer cells: 42 nCPM
macrophages: 36 nCPM

Immune cell

basophil: 83 nTPM
plasmacytoid DC: 54 nTPM
classical monocyte: 47 nTPM
intermediate monocyte: 40 nTPM
myeloid DC: 31 nTPM
non-classical monocyte: 28 nTPM

Brain region

white matter: 25 nTPM
medulla oblongata: 21 nTPM
thalamus: 19 nTPM
pons: 19 nTPM
spinal cord: 17 nTPM
cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0.02
gnomAD missense Z: 0.54

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MILR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MILR1 as an antibody target. Whether an autoantibody or antibody against MILR1 could matter depends on whether native MILR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MILR1 is annotated at the cell surface, where native MILR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MILR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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