MPZL1
Myelin protein zero-like protein 1
Also known as: FLJ21047, MPZL1_HUMAN, PZR
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95297
- Gene
- MPZL1
- Ensembl
- ENSG00000197965
- Chromosome
- 1
- Canonical length
- 269 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Vesicles,Plasma membrane
OverviewNCBI Gene
Predicted to enable structural molecule activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway and cell-cell signaling. Located in cell surface and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
269 residues, UniProt reviewed canonical sequence.
>O95297|MPZL1
1 MAASAGAGAV IAAPDSRRWL WSVLAAALGL LTAGVSALEV YTPKEIFVAN GTQGKLTCKF
61 KSTSTTGGLT SVSWSFQPEG ADTTVSFFHY SQGQVYLGNY PPFKDRISWA GDLDKKDASI
121 NIENMQFIHN GTYICDVKNP PDIVVQPGHI RLYVVEKENL PVFPVWVVVG IVTAVVLGLT
181 LLISMILAVL YRRKNSKRDY TGCSTSESLS PVKQAPRKSP SDTEGLVKSL PSGSHQGPVI
241 YAQLDHSGGH HSDKINKSES VVYADIRKNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MPZL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 85 nTPM
Expression across tissuesHPA
Tissue
- breast: 85 nTPM
- urinary bladder: 70 nTPM
- adipose tissue: 69 nTPM
- salivary gland: 69 nTPM
- placenta: 65 nTPM
- gallbladder: 64 nTPM
Single-cell type
- breast lactating cells: 273 nCPM
- sertoli cells: 239 nCPM
- oligodendrocyte progenitor cells: 221 nCPM
- extravillous trophoblasts: 220 nCPM
- cytotrophoblasts: 212 nCPM
- somatotrophs: 210 nCPM
Immune cell
- neutrophil: 185 nTPM
- plasmacytoid DC: 44 nTPM
- myeloid DC: 39 nTPM
- non-classical monocyte: 35 nTPM
- classical monocyte: 29 nTPM
- intermediate monocyte: 25 nTPM
Brain region
- choroid plexus: 68 nTPM
- pons: 48 nTPM
- midbrain: 47 nTPM
- thalamus: 45 nTPM
- hypothalamus: 42 nTPM
- spinal cord: 39 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.75
- gnomAD pLI
- 0.16
- gnomAD missense Z
- 1.06
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MPZL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MPZL1 as an antibody target. Whether an autoantibody or antibody against MPZL1 could matter depends on whether native MPZL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MPZL1 is annotated at the cell surface, where native MPZL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MPZL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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