PECAM1

Protein identityUniProt · HPA

UniProt accession

P16284

Gene

PECAM1

Ensembl

ENSG00000261371

Chromosome

17

Canonical length

738 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoli,Plasma membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

738 residues, UniProt reviewed canonical sequence.

>P16284|PECAM1
     1  MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD
    61  VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT
   121  AEYQVLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE
   181  KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI
   241  SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG
   301  NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ
   361  KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE
   421  VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN
   481  CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK
   541  EGKPFYQMTS NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK
   601  KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE KMSDPNMEAN
   661  SHYGHNDDVR NHAMKPINDN KEPLNSDVQY TEVQVSSAES HKDLGKKDTE TVYSEVRKAV
   721  PDAVESRYSR TEGSLDGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PECAM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

427 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for PECAM1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

OntologyGO

Biological processes

• angiogenesis
• bicellular tight junction assembly
• cell recognition
• cell surface receptor signaling pathway
• cell-cell adhesion
• cell-cell adhesion via plasma-membrane adhesion molecules
• cellular response to mechanical stimulus
• detection of mechanical stimulus
• diapedesis
• endothelial cell migration
• endothelial cell morphogenesis
• endothelial cell-matrix adhesion
• establishment of endothelial barrier
• glomerular endothelium development
• homophilic cell adhesion via plasma membrane adhesion molecules
• immune response
• leukocyte cell-cell adhesion
• maintenance of blood-brain barrier
• monocyte extravasation
• neutrophil extravasation
• phagocytosis
• positive regulation of cell migration
• positive regulation of intracellular signal transduction
• positive regulation of MAPK cascade
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of protein localization to cell-cell junction
• Rho protein signal transduction
• signal transduction
• vasodilation
• wound healing

Molecular functions

• protein homodimerization activity
• transmembrane signaling receptor activity

Cellular components

• cell-cell contact zone
• cell-cell junction
• cytosol
• external side of plasma membrane
• extracellular exosome
• extracellular space
• membrane raft
• nucleolus
• nucleoplasm
• plasma membrane
• platelet alpha granule membrane
• protein-containing complex
• secretory granule membrane
• smooth muscle contractile fiber

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• IL-40-like, Ig domain
• Immunoglobulin Fc region receptor
• Immunoglobulin domain
• Immunoglobulin domain
• C17orf99 Ig domain

KeywordsUniProt

• Cell adhesion
• Cell junction
• Cell membrane
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Lipoprotein
• Membrane
• Palmitate
• Phagocytosis
• Phosphoprotein
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of PECAM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BDKRB2
• FER
• GNAQ
• PTPN11
• CD177
• SRC