MPIG6B

Protein identityUniProt · HPA

UniProt accession

O95866

Gene

MPIG6B

Ensembl

ENSG00000204420

Chromosome

6

Canonical length

241 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Endoplasmic reticulum,Golgi apparatus,Plasma membrane,Cytosol

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>O95866|MPIG6B
     1  MAVFLQLLPL LLSRAQGNPG ASLDGRPGDR VNLSCGGVSH PIRWVWAPSF PACKGLSKGR
    61  RPILWASSSG TPTVPPLQPF VGRLRSLDSG IRRLELLLSA GDSGTFFCKG RHEDESRTVL
   121  HVLGDRTYCK APGPTHGSVY PQLLIPLLGA GLVLGLGALG LVWWLHRRLP PQPIRPLPRF
   181  APLVKTEPQR PVKEEEPKIP GDLDQEPSLL YADLDHLALS RPRRLSTADP ADASTIYAVV
   241  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPIG6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

7.7 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MPIG6B.

Disease | AllUniProt

Conditions MPIG6B is implicated in, by any mechanism.

• Thrombocytopenia, anemia, and myelofibrosis (THAMY) MIM:617441

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 43 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Thrombocytopenia, anemia, and myelofibrosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.45

gnomAD pLI

0

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• blood coagulation
• erythrocyte differentiation
• integrin-mediated signaling pathway
• megakaryocyte development
• megakaryocyte differentiation
• negative regulation of signal transduction
• platelet formation

Molecular functions

• heparin binding

Cellular components

• cytosol
• endoplasmic reticulum
• Golgi apparatus
• nucleoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G6B family
• G6b-B extracellular V-set Ig-like domain
• G6b-B extracellular V-set Ig-like domain

KeywordsUniProt

• Cell membrane
• Endoplasmic reticulum
• Glycoprotein
• Golgi apparatus
• Heparin-binding
• Membrane
• Phosphoprotein
• Receptor
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MPIG6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PTPN6
• PTPN11