Seroatlas · Human Serome Atlas

DNALI1

Axonemal dynein light intermediate polypeptide 1

Also known as: dJ423B22.5, hp28, IDLC_HUMAN, P28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14645
Gene
DNALI1
Ensembl
ENSG00000163879
Chromosome
1
Canonical length
258 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>O14645|DNALI1
     1  MIPPADSLLK YDTPVLVSRN TEKRSPKARL LKVSPQQPGP SGSAPQPPKT KLPSTPCVPD
    61  PTKQAEEILN AILPPREWVE DTQLWIQQVS STPSTRMDVV HLQEQLDLKL QQRQARETGI
   121  CPVRRELYSQ CFDELIREVT INCAERGLLL LRVRDEIRMT IAAYQTLYES SVAFGMRKAL
   181  QAEQGKSDME RKIAELETEK RDLERQVNEQ KAKCEATEKR ESERRQVEEK KHNEEIQFLK
   241  RTNQQLKAQL EGIIAPKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNALI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 75 nTPM
  • fallopian tube: 51 nTPM
  • testis: 29 nTPM
  • hypothalamus: 15 nTPM
  • epididymis: 14 nTPM
  • pituitary gland: 13 nTPM

Single-cell type

  • late spermatids: 1,405 nCPM
  • early spermatids: 658 nCPM
  • late primary spermatocytes: 514 nCPM
  • respiratory ciliated cells: 448 nCPM
  • fallopian tube ciliated cells: 391 nCPM
  • epididymal efferent duct ciliated cells: 364 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 36 nTPM
  • midbrain: 26 nTPM
  • medulla oblongata: 19 nTPM
  • hypothalamus: 18 nTPM
  • white matter: 17 nTPM
  • spinal cord: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNALI1.

Disease | AllUniProt

Conditions DNALI1 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 83

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.51
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNALI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNALI1 as an antibody target. Whether an autoantibody or antibody against DNALI1 could matter depends on whether native DNALI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNALI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNALI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNALI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...