SERGEF
Secretion-regulating guanine nucleotide exchange factor
Also known as: DelGEF, Gnefr, SRGEF_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UGK8
- Gene
- SERGEF
- Ensembl
- ENSG00000129158
- Chromosome
- 11
- Canonical length
- 458 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in negative regulation of protein secretion. Located in cytosol and nucleoplasm. Biomarker of atherosclerosis. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
458 residues, UniProt reviewed canonical sequence.
>Q9UGK8|SERGEF
1 MEREPSASEA APAAAALFAW GANSYGQLGL GHKEDVLLPQ QLNDFCKPRS VRRITGGGGH
61 SAVVTDGGDL FVCGLNKDGQ LGLGHTEDIP YFTPCKSLFG CPIQQVACGW DFTIMLTENG
121 QVLSCGSNSF GQLGVPHGPR RCVVPQAIEL HKEKVVCIAA GLRHAVAATA SGIVFQWGTG
181 LASCGRRLCP GQTLPLFFTA KEPSRVTGLE NSKAMCVLAG SDHSASLTDA GEVYVWGSNK
241 HGQLANEAAF LPVPQKIEAH CFQNEKVTAI WSGWTHLVAQ TETGKMFTWG RADYGQLGRK
301 LETYEGWKLE KQDSFLPCSR PPNSMPSSPH CLTGATEVSC GSEHNLAIIG GVCYSWGWNE
361 HGMCGDGTEA NVWAPKPVQA LLSSSGLLVG CGAGHSLALC QLPAHPALVQ DPKVTYLSPD
421 AIEDTESQKA MDKERNWKER QSETSTQSQS DWSRNGGLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SERGEF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 61 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 61 nTPM
- amygdala: 54 nTPM
- hippocampal formation: 50 nTPM
- midbrain: 46 nTPM
- cerebellum: 42 nTPM
- hypothalamus: 42 nTPM
Single-cell type
- late spermatids: 397 nCPM
- thyrotrophs: 258 nCPM
- gonadotrophs: 249 nCPM
- somatotrophs: 210 nCPM
- lactotrophs: 184 nCPM
- early spermatids: 181 nCPM
Immune cell
- T-reg: 42 nTPM
- memory CD4 T-cell: 36 nTPM
- naive CD4 T-cell: 35 nTPM
- gdT-cell: 35 nTPM
- naive CD8 T-cell: 31 nTPM
- MAIT T-cell: 29 nTPM
Brain region
- midbrain: 76 nTPM
- cerebellum: 65 nTPM
- pons: 54 nTPM
- cerebral cortex: 50 nTPM
- hypothalamus: 44 nTPM
- hippocampal formation: 43 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.27
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.47
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SERGEF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SERGEF as an antibody target. Whether an autoantibody or antibody against SERGEF could matter depends on whether native SERGEF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SERGEF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SERGEF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...