Seroatlas · Human Serome Atlas

RASSF2

Ras association domain-containing protein 2

Also known as: CENP-34, KIAA0168, RASF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50749
Gene
RASSF2
Ensembl
ENSG00000101265
Chromosome
20
Canonical length
326 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>P50749|RASSF2
     1  MDYSHQTSLV PCGQDKYISK NELLLHLKTY NLYYEGQNLQ LRHREEEDEF IVEGLLNISW
    61  GLRRPIRLQM QDDNERIRPP PSSSSWHSGC NLGAQGTTLK PLTVPKVQIS EVDAPPEGDQ
   121  MPSSTDSRGL KPLQEDTPQL MRTRSDVGVR RRGNVRTPSD QRRIRRHRFS INGHFYNHKT
   181  SVFTPAYGSV TNVRINSTMT TPQVLKLLLN KFKIENSAEE FALYVVHTSG EKQKLKATDY
   241  PLIARILQGP CEQISKVFLM EKDQVEEVTY DVAQYIKFEM PVLKSFIQKL QEEEDREVKK
   301  LMRKYTVLRL MIRQRLEEIA ETPATI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASSF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
286 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 286 nTPM
  • retina: 151 nTPM
  • midbrain: 147 nTPM
  • bone marrow: 86 nTPM
  • hippocampal formation: 85 nTPM
  • cerebral cortex: 80 nTPM

Single-cell type

  • neutrophils: 1,213 nCPM
  • neutrophil progenitors: 425 nCPM
  • rod photoreceptor cells: 324 nCPM
  • monocytes: 230 nCPM
  • monocyte progenitors: 197 nCPM
  • peritubular myoid cells: 180 nCPM

Immune cell

  • neutrophil: 140 nTPM
  • eosinophil: 101 nTPM
  • basophil: 86 nTPM
  • classical monocyte: 62 nTPM
  • non-classical monocyte: 60 nTPM
  • intermediate monocyte: 50 nTPM

Brain region

  • medulla oblongata: 401 nTPM
  • white matter: 346 nTPM
  • cerebellum: 269 nTPM
  • midbrain: 254 nTPM
  • pons: 250 nTPM
  • spinal cord: 231 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
0.9
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RASSF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASSF2 as an antibody target. Whether an autoantibody or antibody against RASSF2 could matter depends on whether native RASSF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASSF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASSF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RASSF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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