C8orf74
Uncharacterized protein C8orf74
Also known as: CH074_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P047
- Gene
- C8orf74
- Ensembl
- ENSG00000171060
- Chromosome
- 8
- Canonical length
- 294 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
No narrative summary is available for C8orf74 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
294 residues, UniProt reviewed canonical sequence.
>Q6P047|C8orf74
1 MALLTPQGVK EVFQLQRPQG RERLRRLLNW EEFDEQRDSR RSILLDTLYE SIIFAVGKGF
61 PWVEVAQVVK FTEELLRETK GCSITEAVTI LGNKLRDYRG HFNTTHLLAL CDYFHHTFIR
121 HYKLYQYVLG QDQQVDLTVA HLEVCMPPHP LPLAEGMDRD LWIHEQQVAT LTEAEAQKRA
181 DVLLLKEALR LERENSLQKA FAAAAPAQPG QVLERQELES LICQAVHTQM ELLQELLQRQ
241 IQNTFAILDL KLQKKTLNLN APTPIPPPIT SHAGQEEALK PQRASKGKKA KARKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C8orf74 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- testis: 16 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 210 nCPM
- early spermatids: 78 nCPM
- late primary spermatocytes: 33 nCPM
- corticotrophs: 0.8 nCPM
- leydig cells: 0.8 nCPM
- peritubular myoid cells: 0.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 0.3 nTPM
- cerebral cortex: 0.3 nTPM
- hippocampal formation: 0.3 nTPM
- medulla oblongata: 0.3 nTPM
- thalamus: 0.3 nTPM
- white matter: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.79
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
InteractionsUniProt · HPA
Protein binding partners of C8orf74 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C8orf74 as an antibody target. Whether an autoantibody or antibody against C8orf74 could matter depends on whether native C8orf74 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C8orf74 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C8orf74 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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