Seroatlas · Human Serome Atlas

FBXO24

F-box only protein 24

Also known as: FBX24, FBX24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75426
Gene: FBXO24
Ensembl: ENSG00000106336
Chromosome: 7
Canonical length: 580 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

580 residues, UniProt reviewed canonical sequence.

>O75426|FBXO24
     1  MGEKAVPLLR RRRVKRSCPS CGSELGVEEK RGKGNPISIQ LFPPELVEHI ISFLPVRDLV
    61  ALGQTCRYFH EVCDGEGVWR RICRRLSPRL QDQGSGVRPW KRAAILNYTK GLYFQAFGGR
   121  RRCLSKSVAP LLAHGYRRFL PTKDHVFILD YVGTLFFLKN ALVSTLGQMQ WKRACRYVVL
   181  CRGAKDFASD PRCDTVYRKY LYVLATREPQ EVVGTTSSRA CDCVEVYLQS SGQRVFKMTF
   241  HHSMTFKQIV LVGQETQRAL LLLTEEGKIY SLVVNETQLD QPRSYTVQLA LRKVSHYLPH
   301  LRVACMTSNQ SSTLYVTDQG GVYFEVHTPG VYRDLFGTLQ AFDPLDQQMP LALSLPAKIL
   361  FCALGYNHLG LVDEFGRIFM QGNNRYGQLG TGDKMDRGEP TQVCYLQRPI TLWCGLNHSL
   421  VLSQSSEFSK ELLGCGCGAG GRLPGWPKGS ASFVKLQVKV PLCACALCAT RECLYILSSH
   481  DIEQHAPYRH LPASRVVGTP EPSLGARAPQ DPGGMAQACE EYLSQIHSCQ TLQDRTEKMK
   541  EIVGWMPLMA AQKDFFWEAL DMLQRAEGGG GGVGPPAPET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

testis: 77 nTPM
cervix: 1.4 nTPM
salivary gland: 1.2 nTPM
skin: 1.2 nTPM
lymph node: 1.1 nTPM
endometrium: 1 nTPM

Single-cell type

late spermatids: 907 nCPM
early spermatids: 667 nCPM
late primary spermatocytes: 196 nCPM
cardiomyocytes: 25 nCPM
epicardial cells: 23 nCPM
early primary spermatocytes: 8.4 nCPM

Immune cell

plasmacytoid DC: 0.5 nTPM
memory B-cell: 0.3 nTPM
neutrophil: 0.3 nTPM
T-reg: 0.3 nTPM
myeloid DC: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

cerebellum: 7.7 nTPM
cerebral cortex: 4.9 nTPM
medulla oblongata: 4.2 nTPM
pons: 4.1 nTPM
thalamus: 3.5 nTPM
white matter: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0
gnomAD missense Z: 1.51
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO24 as an antibody target. Whether an autoantibody or antibody against FBXO24 could matter depends on whether native FBXO24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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