Seroatlas · Human Serome Atlas

GSTCD

Glutathione S-transferase C-terminal domain-containing protein

Also known as: FLJ13273, GSTCD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NEC7
Gene
GSTCD
Ensembl
ENSG00000138780
Chromosome
4
Canonical length
633 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to act upstream of or within respiratory system development and response to lipopolysaccharide. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

633 residues, UniProt reviewed canonical sequence.

>Q8NEC7|GSTCD
     1  MKAIKKSLTE EEYLYLDFSH QTEGCIFPLH TSVTLFLLSY CDCKIFKICL VVTKEVSRDS
    61  SLLRDDLIQD VEIQIISRQE LPPIVQNCCL PAVVERSDNF CRAGLAVVLR HIIQKSYEAD
   121  PLKKELLELL GFKKTCLKAC AEVSQWTRLC ELTIPLAIEN FLRESSDQPP TIPVEILQLE
   181  KKLSEPVRVH NDDKLRRQKL KQQKADGVGP PLTKGKAKSK VHTQETSEGL DSSSKSLELK
   241  VAFSKLTVQE EPATTNREPS HIRKAKASDL PPLEHVFAEG LYFTLADIVL LPCIHHFLVI
   301  ISRKFSEKLV EFPLLASWYQ RIQEVPGVKT AASKCGIQFL HLPKLLTTST EQHPNLCEVP
   361  GVEEQSDPLF IGGPRPTMAK LMEKGIEVMF SPHPCPTWTL DWNVLPAAVS PKEGKMSSDR
   421  ALRKQQQLNN LVYVVTNQAK PGDRIVDFCS GGGHVGIVLA HMLPSCQVTL IENKELSLIR
   481  AKKRSDELGL SNIWFIQANM EYFTGMFNIG VALHACGVAT DMVIEHCIKT RASFVTCPCC
   541  YGFIQNTSKF NFPKSEQFKK TLSYKEHMIL CRFADQTAVQ LPPQRRLIGK QCMCLVDLDR
   601  ARAAEECGYS VQVISMEPES CSPKNNMIVG VPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSTCD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • testis: 10 nTPM
  • retina: 6.8 nTPM
  • breast: 5.1 nTPM
  • bone marrow: 5 nTPM
  • thyroid gland: 5 nTPM
  • tonsil: 4.9 nTPM

Single-cell type

  • early spermatids: 312 nCPM
  • epicardial cells: 200 nCPM
  • late primary spermatocytes: 112 nCPM
  • retinal bipolar cells: 109 nCPM
  • rod photoreceptor cells: 107 nCPM
  • choroid plexus epithelial cells: 102 nCPM

Immune cell

  • neutrophil: 5.5 nTPM
  • naive CD8 T-cell: 1.5 nTPM
  • NK-cell: 1.4 nTPM
  • non-classical monocyte: 1.4 nTPM
  • plasmacytoid DC: 1.3 nTPM
  • intermediate monocyte: 1.1 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • cerebellum: 15 nTPM
  • white matter: 13 nTPM
  • midbrain: 12 nTPM
  • cerebral cortex: 12 nTPM
  • thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
0.34
DepMap mean gene effect
0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GSTCD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSTCD as an antibody target. Whether an autoantibody or antibody against GSTCD could matter depends on whether native GSTCD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSTCD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GSTCD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GSTCD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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