Seroatlas · Human Serome Atlas

STARD10

START domain-containing protein 10

Also known as: CGI-52, NY-CO-28, PCTP2, SDCCAG28, STA10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y365
Gene: STARD10
Ensembl: ENSG00000214530
Chromosome: 11
Canonical length: 291 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable lipid binding activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within bile acid secretion and positive regulation of peroxisome proliferator activated receptor signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q9Y365|STARD10
     1  MEKLAASTEP QGPRPVLGRE SVQVPDDQDF RSFRSECEAE VGWNLTYSRA GVSVWVQAVE
    61  MDRTLHKIKC RMECCDVPAE TLYDVLHDIE YRKKWDSNVI ETFDIARLTV NADVGYYSWR
   121  CPKPLKNRDV ITLRSWLPMG ADYIIMNYSV KHPKYPPRKD LVRAVSIQTG YLIQSTGPKS
   181  CVITYLAQVD PKGSLPKWVV NKSSQFLAPK AMKKMYKACL KYPEWKQKHL PHFKPWLHPE
   241  QSPLPSLALS ELSVQHADSL ENIDESAVAE SREERMGGAG GEGSDDDTSL T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STARD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 710 nTPM

Expression across tissuesHPA

Tissue

liver: 710 nTPM
stomach: 257 nTPM
pancreas: 206 nTPM
testis: 179 nTPM
adrenal gland: 178 nTPM
rectum: 176 nTPM

Single-cell type

late spermatids: 704 nCPM
parietal cells: 226 nCPM
early spermatids: 114 nCPM
gastric chief cells: 108 nCPM
late primary spermatocytes: 84 nCPM
mucous neck cells: 68 nCPM

Immune cell

neutrophil: 21 nTPM
eosinophil: 16 nTPM
basophil: 12 nTPM
NK-cell: 7.4 nTPM
memory B-cell: 4.1 nTPM
classical monocyte: 2.4 nTPM

Brain region

choroid plexus: 55 nTPM
cerebellum: 50 nTPM
pons: 48 nTPM
basal ganglia: 46 nTPM
cerebral cortex: 46 nTPM
medulla oblongata: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 1.34
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid transport

Molecular functions

lipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STARD10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRMT6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STARD10 as an antibody target. Whether an autoantibody or antibody against STARD10 could matter depends on whether native STARD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STARD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STARD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...