Seroatlas · Human Serome Atlas

UBE2L3

Ubiquitin-conjugating enzyme E2 L3

Also known as: UB2L3_HUMAN, UBCH7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P68036
Gene
UBE2L3
Ensembl
ENSG00000185651
Chromosome
22
Canonical length
154 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium transition zone,Cytosol

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>P68036|UBE2L3
     1  MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE
    61  YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP
   121  LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 64 nTPM
  • spinal cord: 63 nTPM
  • cerebral cortex: 62 nTPM
  • amygdala: 62 nTPM
  • midbrain: 60 nTPM
  • hippocampal formation: 55 nTPM

Single-cell type

  • extravillous trophoblasts: 248 nCPM
  • late primary spermatocytes: 246 nCPM
  • megakaryocytes: 241 nCPM
  • syncytiotrophoblasts: 217 nCPM
  • oocytes: 216 nCPM
  • esophageal apical cells: 208 nCPM

Immune cell

  • total PBMC: 86 nTPM
  • myeloid DC: 71 nTPM
  • plasmacytoid DC: 64 nTPM
  • T-reg: 64 nTPM
  • eosinophil: 63 nTPM
  • intermediate monocyte: 62 nTPM

Brain region

  • cerebral cortex: 70 nTPM
  • pons: 65 nTPM
  • thalamus: 63 nTPM
  • medulla oblongata: 62 nTPM
  • hypothalamus: 60 nTPM
  • midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.84
gnomAD missense Z
2.88
DepMap mean gene effect
-1.09
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2L3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2L3 as an antibody target. Whether an autoantibody or antibody against UBE2L3 could matter depends on whether native UBE2L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2L3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...