ZNF746
Zinc finger protein 746
Also known as: FLJ31413, PARIS, ZN746_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6NUN9
- Gene
- ZNF746
- Ensembl
- ENSG00000181220
- Chromosome
- 7
- Canonical length
- 644 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in protein complex oligomerization and regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
644 residues, UniProt reviewed canonical sequence.
>Q6NUN9|ZNF746
1 MAEAVAAPIS PWTMAATIQA MERKIESQAA RLLSLEGRTG MAEKKLADCE KTAVEFGNQL
61 EGKWAVLGTL LQEYGLLQRR LENVENLLRN RNFWILRLPP GSKGESPKEW GKLEDWQKEL
121 YKHVMRGNYE TLVSLDYAIS KPEVLSQIEQ GKEPCNWRRP GPKIPDVPVD PSPGSGPPVP
181 APDLLMQIKQ EGELQLQEQQ ALGVEAWAAG QPDIGEEPWG LSQLDSGAGD ISTDATSGVH
241 SNFSTTIPPT SWQTDLPPHH PSSACSDGTL KLNTAASTED VKIVIKTEVQ EEEVVATPVH
301 PTDLEAHGTL FGPGQATRFF PSPAQEGAWE SQGSSFPSQD PVLGLREPAR PERDMGELSP
361 AVAQEETPPG DWLFGGVRWG WNFRCKPPVG LNPRTGPEGL PYSSPDNGEA ILDPSQAPRP
421 FNEPCKYPGR TKGFGHKPGL KKHPAAPPGG RPFTCATCGK SFQLQVSLSA HQRSCGAPDG
481 SGPGTGGGGS GSGGGGGGSG GGSARDGSAL RCGECGRCFT RPAHLIRHRM LHTGERPFPC
541 TECEKRFTER SKLIDHYRTH TGVRPFTCTV CGKSFIRKDH LRKHQRNHAA GAKTPARGQP
601 LPTPPAPPDP FKSPASKGPL ASTDLVTDWT CGLSVLGPTD GGDMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF746 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 21 nTPM
- testis: 16 nTPM
- spleen: 15 nTPM
- cerebellum: 12 nTPM
- pituitary gland: 10 nTPM
- cerebral cortex: 8.9 nTPM
Single-cell type
- neutrophils: 109 nCPM
- late spermatids: 26 nCPM
- thyrotrophs: 25 nCPM
- corticotrophs: 25 nCPM
- megakaryocytes: 25 nCPM
- late primary spermatocytes: 24 nCPM
Immune cell
- neutrophil: 7 nTPM
- basophil: 2 nTPM
- T-reg: 1.1 nTPM
- memory CD8 T-cell: 1 nTPM
- eosinophil: 0.8 nTPM
- classical monocyte: 0.7 nTPM
Brain region
- hippocampal formation: 30 nTPM
- pons: 29 nTPM
- cerebral cortex: 29 nTPM
- amygdala: 26 nTPM
- medulla oblongata: 26 nTPM
- cerebellum: 26 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.42
- gnomAD pLI
- 0.65
- gnomAD missense Z
- 1.41
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of DNA-templated transcription
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- protein heterooligomerization
- protein homooligomerization
Molecular functions
- DNA-binding transcription factor activity
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- transcription cis-regulatory region binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF746 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF746 as an antibody target. Whether an autoantibody or antibody against ZNF746 could matter depends on whether native ZNF746 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF746 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF746 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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