Seroatlas · Human Serome Atlas

PINK1

Serine/threonine-protein kinase PINK1, mitochondrial

Also known as: BRPK, PARK6, PINK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXM7
Gene
PINK1
Ensembl
ENSG00000158828
Chromosome
1
Canonical length
581 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q9BXM7|PINK1
     1  MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA GPGAEPRRVG
    61  LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV FLAFGLGLGL IEEKQAESRR
   121  AVSACQEIQA IFTQKSKPGP DPLDTRRLQG FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ
   181  NLEVTKSTGL LPGRGPGTSA PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE
   241  LVPASRVALA GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP
   301  SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV DHLVQQGIAH
   361  RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF SSWYVDRGGN GCLMAPEVST
   421  ARPGPRAVID YSKADAWAVG AIAYEIFGLV NPFYGQGKAH LESRSYQEAQ LPALPESVPP
   481  DVRQLVRALL QREASKRPSA RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL
   541  ANRLTEKCCV ETKMKMLFLA NLECETLCQA ALLLCSWRAA L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PINK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
367 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 367 nTPM
  • skeletal muscle: 359 nTPM
  • cerebral cortex: 191 nTPM
  • midbrain: 184 nTPM
  • amygdala: 170 nTPM
  • basal ganglia: 163 nTPM

Single-cell type

  • late spermatids: 245 nCPM
  • esophageal apical cells: 208 nCPM
  • late primary spermatocytes: 179 nCPM
  • hepatocytes: 130 nCPM
  • epididymal clear cells: 116 nCPM
  • neutrophils: 111 nCPM

Immune cell

  • neutrophil: 8.2 nTPM
  • non-classical monocyte: 3.9 nTPM
  • basophil: 3.7 nTPM
  • eosinophil: 3.7 nTPM
  • classical monocyte: 1.6 nTPM
  • naive B-cell: 1.5 nTPM

Brain region

  • thalamus: 275 nTPM
  • midbrain: 265 nTPM
  • spinal cord: 257 nTPM
  • amygdala: 240 nTPM
  • medulla oblongata: 239 nTPM
  • pons: 236 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PINK1.

Disease | AllUniProt

Conditions PINK1 is implicated in, by any mechanism.

Disease | GeneticClinVar

48 pathogenic / likely-pathogenic of 462 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on PINK1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PINK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PINK1 as an antibody target. Whether an autoantibody or antibody against PINK1 could matter depends on whether native PINK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PINK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PINK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PINK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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