Seroatlas · Human Serome Atlas

CHPF

Chondroitin sulfate synthase 2

Also known as: CHSS2_HUMAN, CHSY2, CSS2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZ52
Gene
CHPF
Ensembl
ENSG00000123989
Chromosome
2
Canonical length
775 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Centrosome,Cytosol

OverviewNCBI Gene

Enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

775 residues, UniProt reviewed canonical sequence.

>Q8IZ52|CHPF
     1  MRASLLLSVL RPAGPVAVGI SLGFTLSLLS VTWVEEPCGP GPPQPGDSEL PPRGNTNAAR
    61  RPNSVQPGAE REKPGAGEGA GENWEPRVLP YHPAQPGQAA KKAVRTRYIS TELGIRQRLL
   121  VAVLTSQTTL PTLGVAVNRT LGHRLERVVF LTGARGRRAP PGMAVVTLGE ERPIGHLHLA
   181  LRHLLEQHGD DFDWFFLVPD TTYTEAHGLA RLTGHLSLAS AAHLYLGRPQ DFIGGEPTPG
   241  RYCHGGFGVL LSRMLLQQLR PHLEGCRNDI VSARPDEWLG RCILDATGVG CTGDHEGVHY
   301  SHLELSPGEP VQEGDPHFRS ALTAHPVRDP VHMYQLHKAF ARAELERTYQ EIQELQWEIQ
   361  NTSHLAVDGD QAAAWPVGIP APSRPASRFE VLRWDYFTEQ HAFSCADGSP RCPLRGADRA
   421  DVADVLGTAL EELNRRYHPA LRLQKQQLVN GYRRFDPARG MEYTLDLQLE ALTPQGGRRP
   481  LTRRVQLLRP LSRVEILPVP YVTEASRLTV LLPLAAAERD LAPGFLEAFA TAALEPGDAA
   541  AALTLLLLYE PRQAQRVAHA DVFAPVKAHV AELERRFPGA RVPWLSVQTA APSPLRLMDL
   601  LSKKHPLDTL FLLAGPDTVL TPDFLNRCRM HAISGWQAFF PMHFQAFHPA VAPPQGPGPP
   661  ELGRDTGRFD RQAASEACFY NSDYVAARGR LAAASEQEEE LLESLDVYEL FLHFSSLHVL
   721  RAVEPALLQR YRAQTCSARL SEDLYHRCLQ SVLEGLGSRT QLAMLLFEQE QGNST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHPF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 105 nTPM
  • heart muscle: 91 nTPM
  • ovary: 88 nTPM
  • pituitary gland: 84 nTPM
  • pancreas: 82 nTPM
  • testis: 68 nTPM

Single-cell type

  • syncytiotrophoblasts: 376 nCPM
  • extravillous trophoblasts: 258 nCPM
  • cytotrophoblasts: 189 nCPM
  • migrating cytotrophoblasts: 162 nCPM
  • plasma cells: 116 nCPM
  • decidual stromal cells: 113 nCPM

Immune cell

  • plasmacytoid DC: 6.2 nTPM
  • eosinophil: 5.5 nTPM
  • MAIT T-cell: 2 nTPM
  • NK-cell: 1.9 nTPM
  • gdT-cell: 1.7 nTPM
  • basophil: 1.6 nTPM

Brain region

  • hippocampal formation: 74 nTPM
  • choroid plexus: 74 nTPM
  • medulla oblongata: 68 nTPM
  • thalamus: 67 nTPM
  • white matter: 65 nTPM
  • pons: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.15
gnomAD missense Z
1.03
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHPF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHPF as an antibody target. Whether an autoantibody or antibody against CHPF could matter depends on whether native CHPF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHPF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHPF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHPF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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