Seroatlas · Human Serome Atlas

CHORDC1

Cysteine and histidine-rich domain-containing protein 1

Also known as: CHP-1, CHP1, CHRD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHD1
Gene
CHORDC1
Ensembl
ENSG00000110172
Chromosome
11
Canonical length
332 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables Hsp90 protein binding activity. Predicted to be involved in several processes, including centrosome duplication; chaperone-mediated protein folding; and negative regulation of Rho-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>Q9UHD1|CHORDC1
     1  MALLCYNRGC GQRFDPETNS DDACTYHPGV PVFHDALKGW SCCKRRTTDF SDFLSIVGCT
    61  KGRHNSEKPP EPVKPEVKTT EKKELCELKP KFQEHIIQAP KPVEAIKRPS PDEPMTNLEL
   121  KISASLKQAL DKLKLSSGNE ENKKEEDNDE IKIGTSCKNG GCSKTYQGLE SLEEVCVYHS
   181  GVPIFHEGMK YWSCCRRKTS DFNTFLAQEG CTKGKHMWTK KDAGKKVVPC RHDWHQTGGE
   241  VTISVYAKNS LPELSRVEAN STLLNVHIVF EGEKEFDQNV KLWGVIDVKR SYVTMTATKI
   301  EITMRKAEPM QWASLELPAA KKQEKQKDAT TD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHORDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 26 nTPM
  • hypothalamus: 26 nTPM
  • ovary: 26 nTPM
  • hippocampal formation: 24 nTPM
  • cerebral cortex: 23 nTPM
  • midbrain: 23 nTPM

Single-cell type

  • ependymal cells: 118 nCPM
  • early spermatids: 82 nCPM
  • choroid plexus epithelial cells: 74 nCPM
  • oligodendrocytes: 67 nCPM
  • other brain neurons: 60 nCPM
  • late spermatids: 57 nCPM

Immune cell

  • T-reg: 18 nTPM
  • NK-cell: 17 nTPM
  • intermediate monocyte: 14 nTPM
  • naive CD4 T-cell: 14 nTPM
  • naive CD8 T-cell: 13 nTPM
  • MAIT T-cell: 13 nTPM

Brain region

  • white matter: 34 nTPM
  • cerebral cortex: 23 nTPM
  • hypothalamus: 23 nTPM
  • hippocampal formation: 21 nTPM
  • medulla oblongata: 20 nTPM
  • pons: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.9
gnomAD missense Z
0.74
DepMap mean gene effect
-0.73
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHORDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHORDC1 as an antibody target. Whether an autoantibody or antibody against CHORDC1 could matter depends on whether native CHORDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHORDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHORDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHORDC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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