Seroatlas · Human Serome Atlas

PPP2R3C

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Also known as: C14orf10, FLJ20644, G4-1, G5PR, P2R3C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969Q6
Gene
PPP2R3C
Ensembl
ENSG00000092020
Chromosome
14
Canonical length
453 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Golgi apparatus,Actin filaments,Primary cilium,Cytosol

OverviewNCBI Gene

This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q969Q6|PPP2R3C
     1  MDWKEVLRRR LATPNTCPNK KKSEQELKDE EMDLFTKYYS EWKGGRKNTN EFYKTIPRFY
    61  YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW FLLDKHQTPP MIGEEAMINY
   121  ENFLKVGEKA GAKCKQFFTA KVFAKLLHTD SYGRISIMQF FNYVMRKVWL HQTRIGLSLY
   181  DVAGQGYLRE SDLENYILEL IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI
   241  QDILACSFLD DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR
   301  YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF KLLDIENKGY
   361  LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP KDPLKISLQD LINSNQGDTV
   421  TTILIDLNGF WTYENREALV ANDSENSADL DDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP2R3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • testis: 67 nTPM
  • bone marrow: 40 nTPM
  • skeletal muscle: 32 nTPM
  • lymph node: 29 nTPM
  • spleen: 29 nTPM
  • heart muscle: 25 nTPM

Single-cell type

  • epicardial cells: 1,244 nCPM
  • late primary spermatocytes: 616 nCPM
  • early spermatids: 467 nCPM
  • neutrophils: 388 nCPM
  • late spermatids: 286 nCPM
  • neutrophil progenitors: 206 nCPM

Immune cell

  • eosinophil: 87 nTPM
  • neutrophil: 78 nTPM
  • basophil: 67 nTPM
  • intermediate monocyte: 53 nTPM
  • non-classical monocyte: 43 nTPM
  • classical monocyte: 42 nTPM

Brain region

  • white matter: 20 nTPM
  • hypothalamus: 16 nTPM
  • medulla oblongata: 16 nTPM
  • spinal cord: 15 nTPM
  • basal ganglia: 14 nTPM
  • midbrain: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPP2R3C.

Disease | AllUniProt

Conditions PPP2R3C is implicated in, by any mechanism.

  • Myoectodermal gonadal dysgenesis syndrome (MEGD) MIM:618419
  • Spermatogenic failure 36 (SPGF36) MIM:618420

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 82 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Gonadal dysgenesis, dysmorphic facies, retinal dystrophy, and myopathy
  • Spermatogenic failure 36

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
1.35
DepMap mean gene effect
-0.61
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP2R3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP2R3C as an antibody target. Whether an autoantibody or antibody against PPP2R3C could matter depends on whether native PPP2R3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP2R3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP2R3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP2R3C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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