S100A6

Protein identityUniProt · HPA

UniProt accession

P06703

Gene

S100A6

Ensembl

ENSG00000197956

Chromosome

1

Canonical length

90 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>P06703|S100A6
     1  MACPLDQAIG LLVAIFHKYS GREGDKHTLS KKELKELIQK ELTIGSKLQD AEIARLMEDL
    61  DRNKDQEVNF QEYVTFLGAL ALIYNEALKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

4,483 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for S100A6 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.64

gnomAD pLI

0.18

gnomAD missense Z

0.25

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axonogenesis
• positive regulation of fibroblast proliferation
• signal transduction

Molecular functions

• calcium ion binding
• calcium-dependent protein binding
• monoatomic ion transmembrane transporter activity
• protein homodimerization activity
• S100 protein binding
• tropomyosin binding
• zinc ion binding

Cellular components

• cytoplasm
• cytoplasmic side of plasma membrane
• cytosol
• extracellular exosome
• extracellular matrix
• extracellular region
• nuclear envelope
• nucleus
• perinuclear region of cytoplasm
• plasma membrane
• ruffle

Protein domainsUniProt · Pfam · InterPro

• S100/Calcium binding protein 7/8-like, conserved site
• EF-hand domain
• EF-hand domain pair
• S100/CaBP-9k-type, calcium binding, subdomain
• EF-Hand 1, calcium-binding site
• S-100/ICaBP type calcium binding domain
• Protein S100-A6

KeywordsUniProt

• Acetylation
• Calcium
• Cell membrane
• Cytoplasm
• Membrane
• Metal-binding
• Nucleus
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of S100A6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ANXA11
• ANXA2
• CACYBP
• FKBP4
• PPP5C
• SUGT1
• TP53
• TPPP
• PPID
• S100B
• MDM2