S100A2
Protein S100-A2
Also known as: CAN19, S100L, S10A2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P29034
- Gene
- S100A2
- Ensembl
- ENSG00000196754
- Chromosome
- 1
- Canonical length
- 98 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Plasma membrane,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
98 residues, UniProt reviewed canonical sequence.
>P29034|S100A2
1 MMCSSLEQAL AVLVTTFHKY SCQEGDKFKL SKGEMKELLH KELPSFVGEK VDEEGLKKLM
61 GSLDENSDQQ VDFQEYAVFL ALITVMCNDF FQGCPDRPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against S100A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 3,548 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 3,548 nTPM
- urinary bladder: 1,022 nTPM
- vagina: 800 nTPM
- cervix: 630 nTPM
- kidney: 571 nTPM
- skin: 420 nTPM
Single-cell type
- esophageal suprabasal cells: 32,841 nCPM
- esophageal basal cells: 20,239 nCPM
- esophageal apical cells: 19,225 nCPM
- basal keratinocytes: 10,841 nCPM
- suprabasal keratinocytes: 5,198 nCPM
- epididymal basal cells: 3,108 nCPM
Immune cell
- basophil: 10 nTPM
- neutrophil: 4.4 nTPM
- gdT-cell: 2.3 nTPM
- plasmacytoid DC: 2.2 nTPM
- memory CD4 T-cell: 1.6 nTPM
- T-reg: 1.6 nTPM
Brain region
- medulla oblongata: 5.1 nTPM
- thalamus: 4.1 nTPM
- white matter: 4 nTPM
- hypothalamus: 3.5 nTPM
- midbrain: 3 nTPM
- spinal cord: 3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.96
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.04
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of S100A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads S100A2 as an antibody target. Whether an autoantibody or antibody against S100A2 could matter depends on whether native S100A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
S100A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label S100A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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