Seroatlas · Human Serome Atlas

S100P

Protein S100-P

Also known as: S100P_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P25815
Gene
S100P
Ensembl
ENSG00000163993
Chromosome
4
Canonical length
95 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>P25815|S100P
     1  MTELETAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD
    61  LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
1,656 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 1,656 nTPM
  • stomach: 1,641 nTPM
  • bone marrow: 1,330 nTPM
  • esophagus: 584 nTPM
  • placenta: 446 nTPM
  • vagina: 194 nTPM

Single-cell type

  • esophageal apical cells: 9,538 nCPM
  • urothelial cells: 6,283 nCPM
  • foveolar cells: 4,418 nCPM
  • syncytiotrophoblasts: 3,447 nCPM
  • prostatic club cells: 3,279 nCPM
  • prostatic hillock cells: 2,246 nCPM

Immune cell

  • neutrophil: 2,985 nTPM
  • basophil: 1,797 nTPM
  • eosinophil: 840 nTPM
  • classical monocyte: 41 nTPM
  • total PBMC: 17 nTPM
  • intermediate monocyte: 9.5 nTPM

Brain region

  • cerebral cortex: 13 nTPM
  • pons: 6.6 nTPM
  • cerebellum: 3.3 nTPM
  • choroid plexus: 3.1 nTPM
  • basal ganglia: 2.8 nTPM
  • hippocampal formation: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0.03
gnomAD missense Z
-0.38
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of S100P in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S100P as an antibody target. Whether an autoantibody or antibody against S100P could matter depends on whether native S100P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S100P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label S100P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/S100P. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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