NENF
Neudesin
Also known as: CIR2, NENF_HUMAN, SCIRP10, SPUF
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UMX5
- Gene
- NENF
- Ensembl
- ENSG00000117691
- Chromosome
- 1
- Canonical length
- 172 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Canonical amino-acid sequenceUniProt
172 residues, UniProt reviewed canonical sequence.
>Q9UMX5|NENF
1 MVGPAPRRRL RPLAALALVL ALAPGLPTAR AGQTPRPAER GPPVRLFTEE ELARYGGEEE
61 DQPIYLAVKG VVFDVTSGKE FYGRGAPYNA LTGKDSTRGV AKMSLDPADL THDTTGLTAK
121 ELEALDEVFT KVYKAKYPIV GYTARRILNE DGSPNLDFKP EDQPHFDIKD EFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NENF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 205 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 205 nTPM
- choroid plexus: 195 nTPM
- basal ganglia: 162 nTPM
- midbrain: 153 nTPM
- pituitary gland: 150 nTPM
- heart muscle: 145 nTPM
Single-cell type
- gastric progenitor cells: 433 nCPM
- pancreatic islet cells: 387 nCPM
- cytotrophoblasts: 358 nCPM
- migrating cytotrophoblasts: 293 nCPM
- breast secretory cells: 289 nCPM
- epididymal clear cells: 284 nCPM
Immune cell
- plasmacytoid DC: 14 nTPM
- memory CD8 T-cell: 8.8 nTPM
- memory B-cell: 8.2 nTPM
- myeloid DC: 7.8 nTPM
- intermediate monocyte: 7.1 nTPM
- MAIT T-cell: 6.9 nTPM
Brain region
- white matter: 99 nTPM
- basal ganglia: 88 nTPM
- medulla oblongata: 76 nTPM
- spinal cord: 75 nTPM
- midbrain: 75 nTPM
- cerebellum: 72 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.45
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.11
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NENF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NENF as an antibody target. Whether an autoantibody or antibody against NENF could matter depends on whether native NENF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NENF is annotated as secreted, so native NENF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label NENF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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