TOMM6
Mitochondrial import receptor subunit TOM6 homolog
Also known as: OBTP, Tom6, TOM6_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96B49
- Gene
- TOMM6
- Ensembl
- ENSG00000214736
- Chromosome
- 6
- Canonical length
- 74 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mitochondria
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in protein insertion into mitochondrial outer membrane. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
74 residues, UniProt reviewed canonical sequence.
>Q96B49|TOMM6
1 MASSTVPVSA AGSANETPEI PDNVGDWLRG VYRFATDRND FRRNLILNLG LFAAGVWLAR
61 NLSDIDLMAP QPGVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TOMM6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 315 nTPM
Expression across tissuesHPA
Tissue
- kidney: 315 nTPM
- choroid plexus: 307 nTPM
- heart muscle: 286 nTPM
- skeletal muscle: 274 nTPM
- adrenal gland: 271 nTPM
- epididymis: 255 nTPM
Single-cell type
- other brain neurons: 36 nCPM
- oligodendrocytes: 31 nCPM
- astrocytes: 30 nCPM
- ependymal cells: 29 nCPM
- brain excitatory neurons: 27 nCPM
- bergmann glia: 26 nCPM
Immune cell
- total PBMC: 676 nTPM
- non-classical monocyte: 478 nTPM
- plasmacytoid DC: 476 nTPM
- myeloid DC: 455 nTPM
- intermediate monocyte: 449 nTPM
- classical monocyte: 441 nTPM
Brain region
- choroid plexus: 102 nTPM
- white matter: 102 nTPM
- spinal cord: 93 nTPM
- hypothalamus: 88 nTPM
- cerebral cortex: 87 nTPM
- cerebellum: 85 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.56
- gnomAD pLI
- 0.19
- gnomAD missense Z
- 0.65
- DepMap mean gene effect
- -0.18
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Mitochondrial import receptor subunit TOM6 homologue
- Mitochondrial import receptor subunit TOM6 homolog
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TOMM6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TOMM6 as an antibody target. Whether an autoantibody or antibody against TOMM6 could matter depends on whether native TOMM6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TOMM6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TOMM6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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