TOMM7
Mitochondrial import receptor subunit TOM7 homolog
Also known as: Tom7, TOM7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9P0U1
- Gene
- TOMM7
- Ensembl
- ENSG00000196683
- Chromosome
- 7
- Canonical length
- 55 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012]
Canonical amino-acid sequenceUniProt
55 residues, UniProt reviewed canonical sequence.
>Q9P0U1|TOMM7
1 MVKLSKEAKQ RLQQLFKGSQ FAIRWGFIPL VIYLGFKRGA DPGMPEPTVL SLLWGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TOMM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 1,630 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 1,630 nTPM
- choroid plexus: 1,533 nTPM
- tongue: 1,205 nTPM
- amygdala: 1,059 nTPM
- ovary: 990 nTPM
- basal ganglia: 988 nTPM
Single-cell type
- hepatocytes: 1,381 nCPM
- ovarian stromal cells: 1,239 nCPM
- esophageal suprabasal cells: 1,201 nCPM
- decidual stromal cells: 1,110 nCPM
- epididymal basal cells: 1,110 nCPM
- parietal cells: 1,084 nCPM
Immune cell
- total PBMC: 1,589 nTPM
- naive CD4 T-cell: 1,409 nTPM
- memory B-cell: 1,157 nTPM
- memory CD4 T-cell: 1,067 nTPM
- naive CD8 T-cell: 1,015 nTPM
- naive B-cell: 984 nTPM
Brain region
- choroid plexus: 281 nTPM
- spinal cord: 272 nTPM
- basal ganglia: 268 nTPM
- thalamus: 260 nTPM
- white matter: 256 nTPM
- hypothalamus: 237 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about TOMM7.
Disease | AllUniProt
Conditions TOMM7 is implicated in, by any mechanism.
- Garg-Mishra progeroid syndrome (GMPGS) MIM:620601
Disease | GeneticClinVar
3 pathogenic / likely-pathogenic of 23 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Garg-Mishra progeroid syndrome
- See cases
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.76
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.15
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- positive regulation of protein targeting to mitochondrion
- positive regulation of type 2 mitophagy
- protein import into mitochondrial matrix
- protein insertion into mitochondrial outer membrane
- regulation of protein stability
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Mitochondrial import receptor subunit TOM7
- TOM7 family
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TOMM7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TOMM7 as an antibody target. Whether an autoantibody or antibody against TOMM7 could matter depends on whether native TOMM7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TOMM7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TOMM7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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