Seroatlas · Human Serome Atlas

TOMM20

Mitochondrial import receptor subunit TOM20 homolog

Also known as: KIAA0016, MAS20, MOM19, TOM20, TOM20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15388
Gene: TOMM20
Ensembl: ENSG00000173726
Chromosome: 1
Canonical length: 145 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables mitochondrion targeting sequence binding activity; protein-transporting ATPase activity; and unfolded protein binding activity. Involved in protein targeting to mitochondrion. Located in mitochondria-associated endoplasmic reticulum membrane contact site and mitochondrial outer membrane. Is active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q15388|TOMM20
     1  MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE RAGLSKLPDL
    61  KDAEAVQKFF LEEIQLGEEL LAQGEYEKGV DHLTNAIAVC GQPQQLLQVL QQTLPPPVFQ
   121  MLLTKLPTIS QRIVSAQSLA EDDVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOMM20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 134 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 134 nTPM
cerebral cortex: 134 nTPM
breast: 123 nTPM
spinal cord: 121 nTPM
salivary gland: 118 nTPM
basal ganglia: 113 nTPM

Single-cell type

gastric progenitor cells: 1,086 nCPM
extravillous trophoblasts: 542 nCPM
late spermatids: 451 nCPM
late primary spermatocytes: 423 nCPM
lacrimal acinar cells: 373 nCPM
fallopian secretory cells: 355 nCPM

Immune cell

basophil: 38 nTPM
plasmacytoid DC: 31 nTPM
naive CD4 T-cell: 30 nTPM
memory CD4 T-cell: 25 nTPM
memory CD8 T-cell: 24 nTPM
naive CD8 T-cell: 24 nTPM

Brain region

cerebral cortex: 146 nTPM
basal ganglia: 140 nTPM
hypothalamus: 131 nTPM
spinal cord: 130 nTPM
white matter: 127 nTPM
pons: 125 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0.03
gnomAD missense Z: 1.58
DepMap mean gene effect: -0.66
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mitochondrion targeting sequence binding
unfolded protein binding
protein-transporting ATPase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOMM20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOMM20 as an antibody target. Whether an autoantibody or antibody against TOMM20 could matter depends on whether native TOMM20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOMM20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOMM20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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