Seroatlas · Human Serome Atlas

TIMM23

Mitochondrial import inner membrane translocase subunit Tim23

Also known as: TIM23, TIM23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14925
Gene: TIMM23
Ensembl: ENSG00000265354
Chromosome: 10
Canonical length: 209 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>O14925|TIMM23
     1  MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF
    61  ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQNMAWSK PRNVQILNMV
   121  TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TGGLRGIARG
   181  GLTGLTLTSL YALYNNWEHM KGSLLQQSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMM23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 126 nTPM

Expression across tissuesHPA

Tissue

tongue: 126 nTPM
skeletal muscle: 120 nTPM
choroid plexus: 87 nTPM
heart muscle: 80 nTPM
testis: 75 nTPM
liver: 69 nTPM

Single-cell type

late primary spermatocytes: 236 nCPM
erythrocyte progenitors: 103 nCPM
myonuclei: 100 nCPM
early primary spermatocytes: 96 nCPM
early spermatids: 74 nCPM
esophageal basal cells: 69 nCPM

Immune cell

intermediate monocyte: 131 nTPM
total PBMC: 130 nTPM
non-classical monocyte: 119 nTPM
myeloid DC: 111 nTPM
classical monocyte: 98 nTPM
plasmacytoid DC: 92 nTPM

Brain region

choroid plexus: 57 nTPM
pons: 50 nTPM
midbrain: 49 nTPM
hypothalamus: 48 nTPM
cerebral cortex: 48 nTPM
medulla oblongata: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 0.72
DepMap mean gene effect: -0.92
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIMM23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIMM23 as an antibody target. Whether an autoantibody or antibody against TIMM23 could matter depends on whether native TIMM23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIMM23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIMM23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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