Seroatlas · Human Serome Atlas

PELO

Protein pelota homolog

Also known as: PELO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRX2
Gene: PELO
Ensembl: ENSG00000152684
Chromosome: 5
Canonical length: 385 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Mitotic chromosome

OverviewNCBI Gene

This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q9BRX2|PELO
     1  MKLVRKNIEK DNAGQVTLVP EEPEDMWHTY NLVQVGDSLR ASTIRKVQTE SSTGSVGSNR
    61  VRTTLTLCVE AIDFDSQACQ LRVKGTNIQE NEYVKMGAYH TIELEPNRQF TLAKKQWDSV
   121  VLERIEQACD PAWSADVAAV VMQEGLAHIC LVTPSMTLTR AKVEVNIPRK RKGNCSQHDR
   181  ALERFYEQVV QAIQRHIHFD VVKCILVASP GFVREQFCDY LFQQAVKTDN KLLLENRSKF
   241  LQVHASSGHK YSLKEALCDP TVASRLSDTK AAGEVKALDD FYKMLQHEPD RAFYGLKQVE
   301  KANEAMAIDT LLISDELFRH QDVATRSRYV RLVDSVKENA GTVRIFSSLH VSGEQLSQLT
   361  GVAAILRFPV PELSDQEGDS SSEED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PELO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 17 nTPM
blood vessel: 13 nTPM
spleen: 12 nTPM
skeletal muscle: 12 nTPM
lung: 11 nTPM
placenta: 11 nTPM

Single-cell type

hepatic stellate cells: 6.5 nCPM
gastric chief cells: 2.2 nCPM
endometrial secretory cells: 0.6 nCPM
pericytes: 0.6 nCPM
hematopoietic stem cells: 0.5 nCPM
salivary ionocytes: 0.4 nCPM

Immune cell

basophil: 22 nTPM
neutrophil: 19 nTPM
eosinophil: 7.6 nTPM
memory CD4 T-cell: 6.2 nTPM
myeloid DC: 6.1 nTPM
classical monocyte: 5.9 nTPM

Brain region

thalamus: 12 nTPM
midbrain: 11 nTPM
hypothalamus: 11 nTPM
spinal cord: 11 nTPM
basal ganglia: 10 nTPM
pons: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0.01
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.82
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PELO in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PELO as an antibody target. Whether an autoantibody or antibody against PELO could matter depends on whether native PELO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PELO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PELO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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