Seroatlas · Human Serome Atlas

CLUH

Clustered mitochondria protein homolog

Also known as: CLU_HUMAN, CLU1, KIAA0664

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75153
Gene: CLUH
Ensembl: ENSG00000132361
Chromosome: 17
Canonical length: 1309 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Vesicles

OverviewNCBI Gene

Enables mRNA binding activity. Involved in intracellular distribution of mitochondria and mitochondrion organization. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1309 residues, UniProt reviewed canonical sequence.

>O75153|CLUH
     1  MLLNGDCPES LKKEAAAAEP PRENGLDEAG PGDETTGQEV IVIQDTGFSV KILAPGIEPF
    61  SLQVSPQEMV QEIHQVLMDR EDTCHRTCFS LHLDGNVLDH FSELRSVEGL QEGSVLRVVE
   121  EPYTVREARI HVRHVRDLLK SLDPSDAFNG VDCNSLSFLS VFTDGDLGDS GKRKKGLEMD
   181  PIDCTPPEYI LPGSRERPLC PLQPQNRDWK PLQCLKVLTM SGWNPPPGNR KMHGDLMYLF
   241  VITAEDRQVS ITASTRGFYL NQSTAYHFNP KPASPRFLSH SLVELLNQIS PTFKKNFAVL
   301  QKKRVQRHPF ERIATPFQVY SWTAPQAEHA MDCVRAEDAY TSRLGYEEHI PGQTRDWNEE
   361  LQTTRELPRK NLPERLLRER AIFKVHSDFT AAATRGAMAV IDGNVMAINP SEETKMQMFI
   421  WNNIFFSLGF DVRDHYKDFG GDVAAYVAPT NDLNGVRTYN AVDVEGLYTL GTVVVDYRGY
   481  RVTAQSIIPG ILERDQEQSV IYGSIDFGKT VVSHPRYLEL LERTSRPLKI LRHQVLNDRD
   541  EEVELCSSVE CKGIIGNDGR HYILDLLRTF PPDLNFLPVP GEELPEECAR AGFPRAHRHK
   601  LCCLRQELVD AFVEHRYLLF MKLAALQLMQ QNASQLETPS SLENGGPSSL ESKSEDPPGQ
   661  EAGSEEEGSS ASGLAKVKEL AETIAADDGT DPRSREVIRN ACKAVGSISS TAFDIRFNPD
   721  IFSPGVRFPE SCQDEVRDQK QLLKDAAAFL LSCQIPGLVK DCMEHAVLPV DGATLAEVMR
   781  QRGINMRYLG KVLELVLRSP ARHQLDHVFK IGIGELITRS AKHIFKTYLQ GVELSGLSAA
   841  ISHFLNCFLS SYPNPVAHLP ADELVSKKRN KRRKNRPPGA ADNTAWAVMT PQELWKNICQ
   901  EAKNYFDFDL ECETVDQAVE TYGLQKITLL REISLKTGIQ VLLKEYSFDS RHKPAFTEED
   961  VLNIFPVVKH VNPKASDAFH FFQSGQAKVQ QGFLKEGCEL INEALNLFNN VYGAMHVETC
  1021  ACLRLLARLH YIMGDYAEAL SNQQKAVLMS ERVMGTEHPN TIQEYMHLAL YCFASSQLST
  1081  ALSLLYRARY LMLLVFGEDH PEMALLDNNI GLVLHGVMEY DLSLRFLENA LAVSTKYHGP
  1141  KALKVALSHH LVARVYESKA EFRSALQHEK EGYTIYKTQL GEDHEKTKES SEYLKCLTQQ
  1201  AVALQRTMNE IYRNGSSANI PPLKFTAPSM ASVLEQLNVI NGILFIPLSQ KDLENLKAEV
  1261  ARRHQLQEAS RNRDRAEEPM ATEPAPAGAP GDLGSQPPAA KDPSPSVQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLUH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 127 nTPM

Expression across tissuesHPA

Tissue

liver: 127 nTPM
skeletal muscle: 117 nTPM
heart muscle: 75 nTPM
esophagus: 62 nTPM
adrenal gland: 52 nTPM
tongue: 49 nTPM

Single-cell type

cardiomyocytes: 226 nCPM
hepatocytes: 148 nCPM
oocytes: 97 nCPM
proximal tubule cells: 95 nCPM
esophageal basal cells: 78 nCPM
esophageal suprabasal cells: 71 nCPM

Immune cell

intermediate monocyte: 3.2 nTPM
plasmacytoid DC: 2.7 nTPM
myeloid DC: 2.4 nTPM
naive CD4 T-cell: 2.3 nTPM
classical monocyte: 2.2 nTPM
memory B-cell: 2.2 nTPM

Brain region

choroid plexus: 64 nTPM
thalamus: 58 nTPM
cerebral cortex: 57 nTPM
cerebellum: 55 nTPM
pons: 53 nTPM
medulla oblongata: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 1.84
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mRNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
GSKIP domain superfamily
Tetratricopeptide repeat
CLU domain
CLU domain containing protein
Clustered mitochondria protein, N-terminal
CLU central domain
Translation initiation factor eIF3 subunit 135
Clustered mitochondria
Mitochondrial function, CLU-N-term

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLUH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLUH as an antibody target. Whether an autoantibody or antibody against CLUH could matter depends on whether native CLUH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLUH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLUH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...