Seroatlas · Human Serome Atlas

ZC3H3

Zinc finger CCCH domain-containing protein 3

Also known as: KIAA0150, ZC3H3_HUMAN, ZC3HDC3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXZ2
Gene: ZC3H3
Ensembl: ENSG00000014164
Chromosome: 8
Canonical length: 948 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity; R-SMAD binding activity; and zinc ion binding activity. Predicted to be involved in mRNA transport. Predicted to act upstream of or within mRNA 3'-end processing and positive regulation of activin receptor signaling pathway. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

948 residues, UniProt reviewed canonical sequence.

>Q8IXZ2|ZC3H3
     1  MEEKEILRRQ IRLLQGLIDD YKTLHGNAPA PGTPAASGWQ PPTYHSGRAF SARYPRPSRR
    61  GYSSHHGPSW RKKYSLVNRP PGPSDPPADH AVRPLHGARG GQPPVPQQHV LERQVQLSQG
   121  QNVVIKVKPP SKSGSASASG AQRGSLEEFE ETPWSDQRPR EGEGEPPRGQ LQPSRPTRAR
   181  GTCSVEDPLL VCQKEPGKPR MVKSVGSVGD SPREPRRTVS ESVIAVKASF PSSALPPRTG
   241  VALGRKLGSH SVASCAPQLL GDRRVDAGHT DQPVPSGSVG GPARPASGPR QAREASLVVT
   301  CRTNKFRKNN YKWVAASSKS PRVARRALSP RVAAENVCKA SAGMANKVEK PQLIADPEPK
   361  PRKPATSSKP GSAPSKYKWK ASSPSASSSS SFRWQSEASS KDHASQLSPV LSRSPSGDRP
   421  AVGHSGLKPL SGETPLSAYK VKSRTKIIRR RSSTSLPGDK KSGTSPAATA KSHLSLRRRQ
   481  ALRGKSSPVL KKTPNKGLVQ VTTHRLCRLP PSRAHLPTKE ASSLHAVRTA PTSKVIKTRY
   541  RIVKKTPASP LSAPPFPLSL PSWRARRLSL SRSLVLNRLR PVASGGGKAQ PGSPWWRSKG
   601  YRCIGGVLYK VSANKLSKTS GQPSDAGSRP LLRTGRLDPA GSCSRSLASR AVQRSLAIIR
   661  QARQRREKRK EYCMYYNRFG RCNRGERCPY IHDPEKVAVC TRFVRGTCKK TDGTCPFSHH
   721  VSKEKMPVCS YFLKGICSNS NCPYSHVYVS RKAEVCSDFL KGYCPLGAKC KKKHTLLCPD
   781  FARRGACPRG AQCQLLHRTQ KRHSRRAATS PAPGPSDATA RSRVSASHGP RKPSASQRPT
   841  RQTPSSAALT AAAVAAPPHC PGGSASPSSS KASSSSSSSS SPPASLDHEA PSLQEAALAA
   901  ACSNRLCKLP SFISLQSSPS PGAQPRVRAP RAPLTKDSGK PLHIKPRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

liver: 44 nTPM
kidney: 23 nTPM
small intestine: 20 nTPM
skeletal muscle: 20 nTPM
testis: 19 nTPM
spleen: 18 nTPM

Single-cell type

ocular epithelial cells: 107 nCPM
neutrophils: 95 nCPM
esophageal apical cells: 60 nCPM
urothelial cells: 60 nCPM
monocyte progenitors: 59 nCPM
syncytiotrophoblasts: 58 nCPM

Immune cell

neutrophil: 9.1 nTPM
basophil: 6.6 nTPM
eosinophil: 6.4 nTPM
naive CD4 T-cell: 5.8 nTPM
intermediate monocyte: 5.5 nTPM
total PBMC: 5.4 nTPM

Brain region

white matter: 23 nTPM
cerebral cortex: 23 nTPM
hippocampal formation: 23 nTPM
pons: 23 nTPM
medulla oblongata: 23 nTPM
cerebellum: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.47
gnomAD missense Z: -0.01
DepMap mean gene effect: -0.37
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3H3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H3 as an antibody target. Whether an autoantibody or antibody against ZC3H3 could matter depends on whether native ZC3H3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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