DNA2/NAM7 helicase, helicase domain

Definition

This domain contains the ATP-binding region of DNA2. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Proteins containing this domain also include Nam7 and other helicases. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities [[cite:PMID:10880469], [cite:PMID:22570407]]. Nam7 (also known as Upf1) is an ATP-dependent RNA helicase involved in the nonsense-mediated mRNA decay (NMD) pathway PMID:29236296. This domain is known as AAA_11 in Pfam.

11 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (11 proteins: gene, accession, name)

• AQR
• DNA2
• HELZ
• HELZ2
• IGHMBP2
• MOV10
• MOV10L1
• SETX
• UPF1
• ZGRF1
• ZNFX1