Seroatlas · Human Serome Atlas

L1RE1

LINE-1 retrotransposable element ORF1 protein

Also known as: LORF1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UN81
Gene: L1RE1
Canonical length: 338 aa
Quaternary structure: Homotrimer

OverviewNCBI Gene

No narrative summary is available for L1RE1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>Q9UN81|L1RE1
     1  MGKKQNRKTG NSKTQSASPP PKERSSSPAT EQSWMENDFD ELREEGFRRS NYSELREDIQ
    61  TKGKEVENFE KNLEECITRI TNTEKCLKEL MELKTKAREL REECRSLRSR CDQLEERVSA
   121  MEDEMNEMKR EGKFREKRIK RNEQSLQEIW DYVKRPNLRL IGVPESDVEN GTKLENTLQD
   181  IIQENFPNLA RQANVQIQEI QRTPQRYSSR RATPRHIIVR FTKVEMKEKM LRAAREKGRV
   241  TLKGKPIRLT ADLSAETLQA RREWGPIFNI LKEKNFQPRI SYPAKLSFIS EGEIKYFIDK
   301  QMLRDFVTTR PALKELLKEA LNMERNNRYQ PLQNHAKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against L1RE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45

OntologyGO

Biological processes

retrotransposition

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transposase, L1
L1 transposable element, dsRBD-like domain
L1 transposable element, C-terminal domain
L1 transposable element, RRM domain
L1 transposable element RBD-like domain
L1 transposable element dsRBD-like domain
L1 transposable element, trimerization domain
L1 transposable element trimerization domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of L1RE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads L1RE1 as an antibody target. Whether an autoantibody or antibody against L1RE1 could matter depends on whether native L1RE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

L1RE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label L1RE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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