TAOK1

Protein identityUniProt · HPA

UniProt accession

Q7L7X3

Gene

TAOK1

Ensembl

ENSG00000160551

Chromosome

17

Canonical length

1001 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Plasma membrane,Primary cilium,Cytosol

OverviewNCBI Gene

Enables alpha-tubulin binding activity; beta-tubulin binding activity; and kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; and positive regulation of MAPK cascade. Located in several cellular components, including microtubule cytoskeleton; nuclear body; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1001 residues, UniProt reviewed canonical sequence.

>Q7L7X3|TAOK1
     1  MPSTNRAGSL KDPEIAELFF KEDPEKLFTD LREIGHGSFG AVYFARDVRT NEVVAIKKMS
    61  YSGKQSTEKW QDIIKEVKFL QRIKHPNSIE YKGCYLREHT AWLVMEYCLG SASDLLEVHK
   121  KPLQEVEIAA ITHGALQGLA YLHSHTMIHR DIKAGNILLT EPGQVKLADF GSASMASPAN
   181  SFVGTPYWMA PEVILAMDEG QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN
   241  ESPTLQSNEW SDYFRNFVDS CLQKIPQDRP TSEELLKHIF VLRERPETVL IDLIQRTKDA
   301  VRELDNLQYR KMKKLLFQEA HNGPAVEAQE EEEEQDHGVG RTGTVNSVGS NQSIPSMSIS
   361  ASSQSSSVNS LPDVSDDKSE LDMMEGDHTV MSNSSVIHLK PEEENYREEG DPRTRASDPQ
   421  SPPQVSRHKS HYRNREHFAT IRTASLVTRQ MQEHEQDSEL REQMSGYKRM RRQHQKQLMT
   481  LENKLKAEMD EHRLRLDKDL ETQRNNFAAE MEKLIKKHQA AMEKEAKVMS NEEKKFQQHI
   541  QAQQKKELNS FLESQKREYK LRKEQLKEEL NENQSTPKKE KQEWLSKQKE NIQHFQAEEE
   601  ANLLRRQRQY LELECRRFKR RMLLGRHNLE QDLVREELNK RQTQKDLEHA MLLRQHESMQ
   661  ELEFRHLNTI QKMRCELIRL QHQTELTNQL EYNKRREREL RRKHVMEVRQ QPKSLKSKEL
   721  QIKKQFQDTC KIQTRQYKAL RNHLLETTPK SEHKAVLKRL KEEQTRKLAI LAEQYDHSIN
   781  EMLSTQALRL DEAQEAECQV LKMQLQQELE LLNAYQSKIK MQAEAQHDRE LRELEQRVSL
   841  RRALLEQKIE EEMLALQNER TERIRSLLER QAREIEAFDS ESMRLGFSNM VLSNLSPEAF
   901  SHSYPGASGW SHNPTGGPGP HWGHPMGGPP QAWGHPMQGG PQPWGHPSGP MQGVPRGSSM
   961  GVRNSPQALR RTASGGRTEQ GMSRSTSVTS QISNGSHMSY T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAOK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

21 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAOK1.

Disease | AllUniProt

Conditions TAOK1 is implicated in, by any mechanism.

• Developmental delay with or without intellectual impairment or behavioral abnormalities (DDIB) MIM:619575

Disease | GeneticClinVar

76 pathogenic / likely-pathogenic of 329 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Developmental delay with or without intellectual impairment or behavioral abnormalities
• Inborn genetic diseases
• Neurodevelopmental disorder
• TAOK1-related disorder
• DEVELOPMENTAL DELAY WITHOUT INTELLECTUAL IMPAIRMENT OR BEHAVIORAL ABNORMALITIES

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.27

gnomAD pLI

1

gnomAD missense Z

4.82

DepMap mean gene effect

0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• central nervous system neuron development
• DNA damage response
• DNA repair
• execution phase of apoptosis
• microtubule cytoskeleton organization
• mitotic G2 DNA damage checkpoint signaling
• negative regulation of microtubule depolymerization
• neuron cellular homeostasis
• positive regulation of JNK cascade
• positive regulation of stress-activated MAPK cascade
• regulation of actin cytoskeleton organization
• regulation of cytoskeleton organization
• regulation of microtubule cytoskeleton organization

Molecular functions

• alpha-tubulin binding
• ATP binding
• beta-tubulin binding
• kinase activity
• protein kinase activity
• protein serine kinase activity
• protein serine/threonine kinase activator activity
• protein serine/threonine kinase activity
• tau protein binding
• tau-protein kinase activity
• transferase activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• microtubule cytoskeleton
• nuclear body
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• TAO Serine/Threonine-Protein Kinase
• Protein kinase domain

KeywordsUniProt

• Apoptosis
• ATP-binding
• Coiled coil
• Cytoplasm
• DNA damage
• DNA repair
• Intellectual disability
• Kinase
• Nucleotide-binding
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of TAOK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAP2K3
• MAP3K7
• SPRED1
• TESK1