Seroatlas · Human Serome Atlas

PELI3

E3 ubiquitin-protein ligase pellino homolog 3

Also known as: MGC35521, PELI3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N2H9
Gene
PELI3
Ensembl
ENSG00000174516
Chromosome
11
Canonical length
469 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q8N2H9|PELI3
     1  MVLEGNPEVG SPRTSDLQHR GNKGSCVLSS PGEDAQPGEE PIKYGELIVL GCCEEGGEET
    61  EAQRGEVTGP RAHSCYNGCL ASGDKGRRRS RLALSRRSHA NGVKPDVMHH ISTPLVSKAL
   121  SNRGQHSISY TLSRSHSVIV EYTHDSDTDM FQIGRSTENM IDFVVTDTSP GGGAAEGPSA
   181  QSTISRYACR ILCDRRPPYT ARIYAAGFDA SSNIFLGERA AKWRTPDGLM DGLTTNGVLV
   241  MHPAGGFSED SAPGVWREIS VCGNVYTLRD SRSAQQRGKL VENESNVLQD GSLIDLCGAT
   301  LLWRTPAGLL RAPTLKQLEA QRQEANAARP QCPVGLSTLA FPSPARGRTA PDKQQPWVYV
   361  RCGHVHGYHG WGCRRERGPQ ERECPLCRLV GPYVPLWLGQ EAGLCLDPGP PSHAFAPCGH
   421  VCSEKTARYW AQTPLPHGTH AFHAACPFCG AWLTGEHGCV RLIFQGPLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PELI3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 38 nTPM
  • cerebellum: 29 nTPM
  • hippocampal formation: 26 nTPM
  • basal ganglia: 22 nTPM
  • amygdala: 22 nTPM
  • hypothalamus: 20 nTPM

Single-cell type

  • neuroendocrine cells: 21 nCPM
  • pancreatic islet cells: 20 nCPM
  • late spermatids: 16 nCPM
  • retinal amacrine cells: 13 nCPM
  • smooth muscle cells: 11 nCPM
  • other brain neurons: 10 nCPM

Immune cell

  • non-classical monocyte: 3.4 nTPM
  • naive B-cell: 1.5 nTPM
  • myeloid DC: 1.4 nTPM
  • memory B-cell: 1.2 nTPM
  • memory CD8 T-cell: 1.2 nTPM
  • classical monocyte: 1 nTPM

Brain region

  • cerebral cortex: 74 nTPM
  • pons: 54 nTPM
  • medulla oblongata: 49 nTPM
  • cerebellum: 49 nTPM
  • hippocampal formation: 48 nTPM
  • thalamus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.01
gnomAD missense Z
2.43
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PELI3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PELI3 as an antibody target. Whether an autoantibody or antibody against PELI3 could matter depends on whether native PELI3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PELI3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PELI3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PELI3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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