Seroatlas · Human Serome Atlas

MAPK8IP1

C-Jun-amino-terminal kinase-interacting protein 1

Also known as: IB1, JIP-1, JIP1, JIP1_HUMAN, PRKM8IP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UQF2
Gene
MAPK8IP1
Ensembl
ENSG00000121653
Chromosome
11
Canonical length
711 aa
Protein class
Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

711 residues, UniProt reviewed canonical sequence.

>Q9UQF2|MAPK8IP1
     1  MAERESGGLG GGAASPPAAS PFLGLHIASP PNFRLTHDIS LEEFEDEDLS EITDECGISL
    61  QCKDTLSLRP PRAGLLSAGG GGAGSRLQAE MLQMDLIDAT GDTPGAEDDE EDDDEERAAR
   121  RPGAGPPKAE SGQEPASRGQ GQSQGQSQGP GSGDTYRPKR PTTLNLFPQV PRSQDTLNNN
   181  SLGKKHSWQD RVSRSSSPLK TGEQTPPHEH ICLSDELPPQ SGPAPTTDRG TSTDSPCRRS
   241  TATQMAPPGG PPAAPPGGRG HSHRDRIHYQ ADVRLEATEE IYLTPVQRPP DAAEPTSAFL
   301  PPTESRMSVS SDPDPAAYPS TAGRPHPSIS EEEEGFDCLS SPERAEPPGG GWRGSLGEPP
   361  PPPRASLSSD TSALSYDSVK YTLVVDEHAQ LELVSLRPCF GDYSDESDSA TVYDNCASVS
   421  SPYESAIGEE YEEAPRPQPP ACLSEDSTPD EPDVHFSKKF LNVFMSGRSR SSSAESFGLF
   481  SCIINGEEQE QTHRAIFRFV PRHEDELELE VDDPLLVELQ AEDYWYEAYN MRTGARGVFP
   541  AYYAIEVTKE PEHMAALAKN SDWVDQFRVK FLGSVQVPYH KGNDVLCAAM QKIATTRRLT
   601  VHFNPPSSCV LEISVRGVKI GVKADDSQEA KGNKCSHFFQ LKNISFCGYH PKNNKYFGFI
   661  TKHPADHRFA CHVFVSEDST KALAESVGRA FQQFYKQFVE YTCPTEDIYL E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPK8IP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
256 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 256 nTPM
  • hippocampal formation: 215 nTPM
  • amygdala: 178 nTPM
  • cerebral cortex: 173 nTPM
  • midbrain: 145 nTPM
  • basal ganglia: 121 nTPM

Single-cell type

  • oligodendrocytes: 76 nCPM
  • gonadotrophs: 64 nCPM
  • retinal horizontal cells: 52 nCPM
  • corticotrophs: 50 nCPM
  • late spermatids: 43 nCPM
  • somatotrophs: 39 nCPM

Immune cell

  • basophil: 0.8 nTPM
  • NK-cell: 0.5 nTPM
  • neutrophil: 0.4 nTPM
  • classical monocyte: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hippocampal formation: 338 nTPM
  • white matter: 327 nTPM
  • medulla oblongata: 316 nTPM
  • cerebral cortex: 304 nTPM
  • pons: 289 nTPM
  • thalamus: 278 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAPK8IP1.

Disease | AllUniProt

Conditions MAPK8IP1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
1.49
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPK8IP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPK8IP1 as an antibody target. Whether an autoantibody or antibody against MAPK8IP1 could matter depends on whether native MAPK8IP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPK8IP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAPK8IP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAPK8IP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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