PPM1L

Protein identityUniProt · HPA

UniProt accession

Q5SGD2

Gene

PPM1L

Ensembl

ENSG00000163590

Chromosome

3

Canonical length

360 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q5SGD2|PPM1L
     1  MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK SSRDAVKMVK
    61  GKVAEIMQND RLGGLDVLEA EFSKTWEFKN HNVAVYSIQG RRDHMEDRFE VLTDLANKTH
   121  PSIFGIFDGH GGETAAEYVK SRLPEALKQH LQDYEKDKEN SVLSYQTILE QQILSIDREM
   181  LEKLTVSYDE AGTTCLIALL SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK
   241  RIKRAGGFIS FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA
   301  SDGLWDAFSN EEAVRFIKER LDEPHFGAKS IVLQSFYRGC PDNITVMVVK FRNSSKTEEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPM1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

21 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.54

gnomAD pLI

0.47

gnomAD missense Z

2.06

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor protein serine/threonine kinase signaling pathway
• MAPK cascade
• signal transduction
• sphingolipid biosynthetic process

Molecular functions

• metal ion binding
• protein serine/threonine phosphatase activity

Cellular components

• endoplasmic reticulum membrane
• extracellular exosome

Protein domainsUniProt · Pfam · InterPro

• PPM-type phosphatase, divalent cation binding
• PPM-type phosphatase-like domain
• Protein phosphatase 2C
• PPM-type phosphatase-like domain superfamily
• Protein phosphatase 2C

KeywordsUniProt

• Hydrolase
• Magnesium
• Manganese
• Membrane
• Metal-binding
• Protein phosphatase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of PPM1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAP3K5
• MAP3K7