Seroatlas · Human Serome Atlas

PELI2

E3 ubiquitin-protein ligase pellino homolog 2

Also known as: PELI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAT8
Gene: PELI2
Ensembl: ENSG00000139946
Chromosome: 14
Canonical length: 420 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Intermediate filaments,Centriolar satellite,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Acts upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q9HAT8|PELI2
     1  MFSPGQEEHC APNKEPVKYG ELVVLGYNGA LPNGDRGRRK SRFALYKRPK ANGVKPSTVH
    61  VISTPQASKA ISCKGQHSIS YTLSRNQTVV VEYTHDKDTD MFQVGRSTES PIDFVVTDTI
   121  SGSQNTDEAQ ITQSTISRFA CRIVCDRNEP YTARIFAAGF DSSKNIFLGE KAAKWKNPDG
   181  HMDGLTTNGV LVMHPRGGFT EESQPGVWRE ISVCGDVYTL RETRSAQQRG KLVESETNVL
   241  QDGSLIDLCG ATLLWRTADG LFHTPTQKHI EALRQEINAA RPQCPVGLNT LAFPSINRKE
   301  VVEEKQPWAY LSCGHVHGYH NWGHRSDTEA NERECPMCRT VGPYVPLWLG CEAGFYVDAG
   361  PPTHAFTPCG HVCSEKSAKY WSQIPLPHGT HAFHAACPFC ATQLVGEQNC IKLIFQGPID

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PELI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

pancreas: 27 nTPM
thymus: 18 nTPM
bone marrow: 18 nTPM
retina: 14 nTPM
stomach: 14 nTPM
ovary: 13 nTPM

Single-cell type

neutrophils: 1,063 nCPM
pancreatic acinar cells: 709 nCPM
neutrophil progenitors: 472 nCPM
tuft cells: 450 nCPM
pituicytes/fscs: 403 nCPM
retinal ganglion cells: 379 nCPM

Immune cell

neutrophil: 5.6 nTPM
eosinophil: 2.4 nTPM
classical monocyte: 1.9 nTPM
myeloid DC: 1.3 nTPM
intermediate monocyte: 1 nTPM
basophil: 0.9 nTPM

Brain region

cerebellum: 65 nTPM
midbrain: 31 nTPM
thalamus: 29 nTPM
pons: 27 nTPM
medulla oblongata: 26 nTPM
white matter: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.83
gnomAD missense Z: 1.6
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PELI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PELI2 as an antibody target. Whether an autoantibody or antibody against PELI2 could matter depends on whether native PELI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PELI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PELI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...