Seroatlas · Human Serome Atlas

RSAD2

S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Also known as: cig5, RSAD2_HUMAN, vig1, Viperin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WXG1
Gene
RSAD2
Ensembl
ENSG00000134321
Chromosome
2
Canonical length
361 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center,Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is an interferon-inducible antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes. The protein plays a role in cellular antiviral response and innate immune signaling. Antiviral effects result from inhibition of viral RNA replication, interference in the secretory pathway, binding to viral proteins and dysregulation of cellular lipid metabolism. The protein has been found to inhibit both DNA and RNA viruses, including influenza virus, human immunodeficiency virus (HIV-1) and Zika virus. [provided by RefSeq, Sep 2020]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q8WXG1|RSAD2
     1  MWVLTPAAFA GKLLSVFRQP LSSLWRSLVP LFCWLRATFW LLATKRRKQQ LVLRGPDETK
    61  EEEEDPPLPT TPTSVNYHFT RQCNYKCGFC FHTAKTSFVL PLEEAKRGLL LLKEAGMEKI
   121  NFSGGEPFLQ DRGEYLGKLV RFCKVELRLP SVSIVSNGSL IRERWFQNYG EYLDILAISC
   181  DSFDEEVNVL IGRGQGKKNH VENLQKLRRW CRDYRVAFKI NSVINRFNVE EDMTEQIKAL
   241  NPVRWKVFQC LLIEGENCGE DALREAERFV IGDEEFERFL ERHKEVSCLV PESNQKMKDS
   301  YLILDEYMRF LNCRKGRKDP SKSILDVGVE EAIKFSGFDE KMFLKRGGKY IWSKADLKLD
   361  W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSAD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 20 nTPM
  • bone marrow: 13 nTPM
  • spleen: 9.5 nTPM
  • lung: 7.8 nTPM
  • tongue: 7.1 nTPM
  • thymus: 6.8 nTPM

Single-cell type

  • colonocytes: 138 nCPM
  • epididymal basal cells: 109 nCPM
  • foveolar cells: 94 nCPM
  • pancreatic islet cells: 64 nCPM
  • epididymal efferent duct ciliated cells: 52 nCPM
  • retinal pigment epithelial cells: 51 nCPM

Immune cell

  • eosinophil: 43 nTPM
  • basophil: 31 nTPM
  • neutrophil: 25 nTPM
  • intermediate monocyte: 7.5 nTPM
  • non-classical monocyte: 7 nTPM
  • classical monocyte: 4.9 nTPM

Brain region

  • spinal cord: 24 nTPM
  • medulla oblongata: 10 nTPM
  • pons: 8.9 nTPM
  • choroid plexus: 8.7 nTPM
  • basal ganglia: 6.7 nTPM
  • white matter: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.81
gnomAD pLI
0
gnomAD missense Z
0.17
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSAD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSAD2 as an antibody target. Whether an autoantibody or antibody against RSAD2 could matter depends on whether native RSAD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSAD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSAD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RSAD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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