Seroatlas · Human Serome Atlas

ZC3H12A

Endoribonuclease ZC3H12A

Also known as: FLJ23231, MCPIP1, Regnase-1, ZC12A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5D1E8
Gene
ZC3H12A
Ensembl
ENSG00000163874
Chromosome
1
Canonical length
599 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytoplasmic bodies

OverviewNCBI Gene

ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

599 residues, UniProt reviewed canonical sequence.

>Q5D1E8|ZC3H12A
     1  MSGPCGEKPV LEASPTMSLW EFEDSHSRQG TPRPGQELAA EEASALELQM KVDFFRKLGY
    61  SSTEIHSVLQ KLGVQADTNT VLGELVKHGT ATERERQTSP DPCPQLPLVP RGGGTPKAPN
   121  LEPPLPEEEK EGSDLRPVVI DGSNVAMSHG NKEVFSCRGI LLAVNWFLER GHTDITVFVP
   181  SWRKEQPRPD VPITDQHILR ELEKKKILVF TPSRRVGGKR VVCYDDRFIV KLAYESDGIV
   241  VSNDTYRDLQ GERQEWKRFI EERLLMYSFV NDKFMPPDDP LGRHGPSLDN FLRKKPLTLE
   301  HRKQPCPYGR KCTYGIKCRF FHPERPSCPQ RSVADELRAN ALLSPPRAPS KDKNGRRPSP
   361  SSQSSSLLTE SEQCSLDGKK LGAQASPGSR QEGLTQTYAP SGRSLAPSGG SGSSFGPTDW
   421  LPQTLDSLPY VSQDCLDSGI GSLESQMSEL WGVRGGGPGE PGPPRAPYTG YSPYGSELPA
   481  TAAFSAFGRA MGAGHFSVPA DYPPAPPAFP PREYWSEPYP LPPPTSVLQE PPVQSPGAGR
   541  SPWGRAGSLA KEQASVYTKL CGVFPPHLVE AVMGRFPQLL DPQQLAAEIL SYKSQHPSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H12A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
129 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 129 nTPM
  • skin: 52 nTPM
  • esophagus: 45 nTPM
  • lung: 40 nTPM
  • urinary bladder: 37 nTPM
  • gallbladder: 34 nTPM

Single-cell type

  • epididymal basal cells: 350 nCPM
  • endometrial secretory cells: 243 nCPM
  • epididymal clear cells: 225 nCPM
  • breast secretory cells: 223 nCPM
  • fallopian secretory cells: 146 nCPM
  • epididymal efferent duct absorptive cells: 144 nCPM

Immune cell

  • neutrophil: 5.6 nTPM
  • eosinophil: 4 nTPM
  • naive B-cell: 3.9 nTPM
  • NK-cell: 3.6 nTPM
  • MAIT T-cell: 3.3 nTPM
  • gdT-cell: 3.1 nTPM

Brain region

  • cerebral cortex: 7.4 nTPM
  • pons: 7.3 nTPM
  • medulla oblongata: 7.2 nTPM
  • hypothalamus: 6.9 nTPM
  • thalamus: 6.7 nTPM
  • midbrain: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.14
gnomAD missense Z
2.18
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3H12A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H12A as an antibody target. Whether an autoantibody or antibody against ZC3H12A could matter depends on whether native ZC3H12A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H12A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H12A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZC3H12A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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