Seroatlas · Human Serome Atlas

SIGIRR

Single Ig IL-1-related receptor

Also known as: IL-1R8, SIGIR_HUMAN, TIR8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IA17
Gene: SIGIRR
Ensembl: ENSG00000185187
Chromosome: 11
Canonical length: 410 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Involved in negative regulation of Toll signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q6IA17|SIGIRR
     1  MPGVCDRAPD FLSPSEDQVL RPALGSSVAL NCTAWVVSGP HCSLPSVQWL KDGLPLGIGG
    61  HYSLHEYSWV KANLSEVLVS SVLGVNVTST EVYGAFTCSI QNISFSSFTL QRAGPTSHVA
   121  AVLASLLVLL ALLLAALLYV KCRLNVLLWY QDAYGEVEIN DGKLYDAYVS YSDCPEDRKF
   181  VNFILKPQLE RRRGYKLFLD DRDLLPRAEP SADLLVNLSR CRRLIVVLSD AFLSRAWCSH
   241  SFREGLCRLL ELTRRPIFIT FEGQRRDPAH PALRLLRQHR HLVTLLLWRP GSVTPSSDFW
   301  KEVQLALPRK VQYRPVEGDP QTQLQDDKDP MLILRGRVPE GRALDSEVDP DPEGDLGVRG
   361  PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD FYCLVSKDDM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIGIRR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

liver: 90 nTPM
spleen: 68 nTPM
kidney: 66 nTPM
pancreas: 45 nTPM
small intestine: 45 nTPM
colon: 43 nTPM

Single-cell type

hepatocytes: 451 nCPM
melanocytes: 151 nCPM
colonocytes: 131 nCPM
tuft cells: 127 nCPM
fallopian tube ciliated cells: 117 nCPM
epididymal principal cells: 106 nCPM

Immune cell

gdT-cell: 124 nTPM
memory CD8 T-cell: 108 nTPM
T-reg: 106 nTPM
NK-cell: 103 nTPM
memory CD4 T-cell: 102 nTPM
MAIT T-cell: 99 nTPM

Brain region

medulla oblongata: 28 nTPM
pons: 26 nTPM
white matter: 21 nTPM
thalamus: 20 nTPM
spinal cord: 18 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: -0.05
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIGIRR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIGIRR as an antibody target. Whether an autoantibody or antibody against SIGIRR could matter depends on whether native SIGIRR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIGIRR is annotated at the cell surface, where native SIGIRR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIGIRR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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