Seroatlas · Human Serome Atlas

HSPB1

Heat shock protein beta-1

Also known as: CMT2F, Hs.76067, Hsp25, HSP27, HSP28, HSPB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04792
Gene
HSPB1
Ensembl
ENSG00000106211
Chromosome
7
Canonical length
205 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>P04792|HSPB1
     1  MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP
    61  AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI
   121  TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT
   181  IPVTFESRAQ LGGPEAAKSD ETAAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
6,919 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 6,919 nTPM
  • blood vessel: 4,856 nTPM
  • skeletal muscle: 4,326 nTPM
  • vagina: 4,058 nTPM
  • heart muscle: 3,367 nTPM
  • cervix: 3,090 nTPM

Single-cell type

  • esophageal apical cells: 36,565 nCPM
  • esophageal suprabasal cells: 24,429 nCPM
  • esophageal basal cells: 10,115 nCPM
  • decidual stromal cells: 6,656 nCPM
  • epididymal efferent duct absorptive cells: 4,667 nCPM
  • epididymal efferent duct ciliated cells: 3,289 nCPM

Immune cell

  • memory B-cell: 116 nTPM
  • non-classical monocyte: 113 nTPM
  • naive B-cell: 106 nTPM
  • naive CD4 T-cell: 103 nTPM
  • memory CD4 T-cell: 93 nTPM
  • naive CD8 T-cell: 89 nTPM

Brain region

  • hypothalamus: 721 nTPM
  • medulla oblongata: 602 nTPM
  • pons: 563 nTPM
  • choroid plexus: 543 nTPM
  • white matter: 532 nTPM
  • thalamus: 500 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSPB1.

Disease | AllUniProt

Conditions HSPB1 is implicated in, by any mechanism.

  • Charcot-Marie-Tooth disease, axonal, type 2F (CMT2F) MIM:606595
  • Neuronopathy, distal hereditary motor, autosomal dominant 3 (HMND3) MIM:608634

Disease | GeneticClinVar

42 pathogenic / likely-pathogenic of 421 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on HSPB1 was assayed in.

ReferencesPubMed · IEDB

Publications for HSPB1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

17 publications

Show 12 more

Reference: B cellIEDB

1 publication

Reference: T cellIEDB

2 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0
gnomAD missense Z
-0.51
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPB1 as an antibody target. Whether an autoantibody or antibody against HSPB1 could matter depends on whether native HSPB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSPB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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