Seroatlas · Human Serome Atlas

SPIN1

Spindlin-1

Also known as: SPIN, SPIN1_HUMAN, TDRD24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y657
Gene: SPIN1
Ensembl: ENSG00000106723
Chromosome: 9
Canonical length: 262 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables histone reader activity and methylated histone binding activity. Involved in positive regulation of DNA-templated transcription; positive regulation of Wnt signaling pathway; and rRNA transcription. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q9Y657|SPIN1
     1  MKTPFGKTPG QRSRADAGHA GVSANMMKKR TSHKKHRSSV GPSKPVSQPR RNIVGCRIQH
    61  GWKEGNGPVT QWKGTVLDQV PVNPSLYLIK YDGFDCVYGL ELNKDERVSA LEVLPDRVAT
   121  SRISDAHLAD TMIGKAVEHM FETEDGSKDE WRGMVLARAP VMNTWFYITY EKDPVLYMYQ
   181  LLDDYKEGDL RIMPDSNDSP PAEREPGEVV DSLVGKQVEY AKEDGSKRTG MVIHQVEAKP
   241  SVYFIKFDDD FHIYVYDLVK TS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

epididymis: 73 nTPM
endometrium: 57 nTPM
cervix: 56 nTPM
cerebral cortex: 52 nTPM
ovary: 50 nTPM
fallopian tube: 48 nTPM

Single-cell type

choroid plexus epithelial cells: 422 nCPM
sertoli cells: 413 nCPM
ependymal cells: 332 nCPM
pituitary stem cells: 311 nCPM
distal convoluted tubule cells: 305 nCPM
renal connecting tubule cells: 264 nCPM

Immune cell

basophil: 7.4 nTPM
myeloid DC: 5 nTPM
naive CD8 T-cell: 4.5 nTPM
eosinophil: 4.2 nTPM
MAIT T-cell: 4.1 nTPM
memory CD8 T-cell: 4 nTPM

Brain region

cerebral cortex: 84 nTPM
basal ganglia: 82 nTPM
hypothalamus: 82 nTPM
midbrain: 73 nTPM
white matter: 71 nTPM
hippocampal formation: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.97
gnomAD missense Z: 3.25
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPIN1 as an antibody target. Whether an autoantibody or antibody against SPIN1 could matter depends on whether native SPIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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