Seroatlas · Human Serome Atlas

TPT1

Translationally-controlled tumor protein

Also known as: fortilin, TCTP, TCTP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P13693
Gene
TPT1
Ensembl
ENSG00000133112
Chromosome
13
Canonical length
172 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>P13693|TPT1
     1  MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE
    61  GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK GKLEEQRPER VKPFMTGAAE
   121  QIKHILANFK NYQFFIGENM NPDGMVALLD YREDGVTPYM IFFKDGLEME KC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
21,778 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 21,778 nTPM
  • tongue: 12,959 nTPM
  • pancreas: 10,034 nTPM
  • salivary gland: 7,971 nTPM
  • ovary: 6,743 nTPM
  • bone marrow: 6,618 nTPM

Single-cell type

  • esophageal apical cells: 28,843 nCPM
  • pancreatic acinar cells: 14,448 nCPM
  • esophageal suprabasal cells: 12,501 nCPM
  • epididymal principal cells: 9,855 nCPM
  • enterocytes: 9,766 nCPM
  • breast lactating cells: 9,441 nCPM

Immune cell

  • total PBMC: 3,208 nTPM
  • naive CD4 T-cell: 1,951 nTPM
  • memory CD4 T-cell: 1,880 nTPM
  • MAIT T-cell: 1,834 nTPM
  • T-reg: 1,817 nTPM
  • naive CD8 T-cell: 1,642 nTPM

Brain region

  • spinal cord: 1,448 nTPM
  • white matter: 1,411 nTPM
  • hypothalamus: 1,393 nTPM
  • medulla oblongata: 1,367 nTPM
  • choroid plexus: 1,307 nTPM
  • basal ganglia: 1,143 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.81
gnomAD missense Z
1.53
DepMap mean gene effect
-1
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPT1 as an antibody target. Whether an autoantibody or antibody against TPT1 could matter depends on whether native TPT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TPT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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