Seroatlas · Human Serome Atlas

PGM2

Phosphopentomutase

Also known as: FLJ10983, PGM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96G03
Gene: PGM2
Ensembl: ENSG00000169299
Chromosome: 4
Canonical length: 612 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

Enables phosphoglucomutase activity and phosphopentomutase activity. Predicted to be involved in purine ribonucleoside salvage. Predicted to act upstream of or within glucose metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

612 residues, UniProt reviewed canonical sequence.

>Q96G03|PGM2
     1  MAAPEGSGLG EDARLDQETA QWLRWDKNSL TLEAVKRLIA EGNKEELRKC FGARMEFGTA
    61  GLRAAMGPGI SRMNDLTIIQ TTQGFCRYLE KQFSDLKQKG IVISFDARAH PSSGGSSRRF
   121  ARLAATTFIS QGIPVYLFSD ITPTPFVPFT VSHLKLCAGI MITASHNPKQ DNGYKVYWDN
   181  GAQIISPHDK GISQAIEENL EPWPQAWDDS LIDSSPLLHN PSASINNDYF EDLKKYCFHR
   241  SVNRETKVKF VHTSVHGVGH SFVQSAFKAF DLVPPEAVPE QKDPDPEFPT VKYPNPEEGK
   301  GVLTLSFALA DKTKARIVLA NDPDADRLAV AEKQDSGEWR VFSGNELGAL LGWWLFTSWK
   361  EKNQDRSALK DTYMLSSTVS SKILRAIALK EGFHFEETLT GFKWMGNRAK QLIDQGKTVL
   421  FAFEEAIGYM CCPFVLDKDG VSAAVISAEL ASFLATKNLS LSQQLKAIYV EYGYHITKAS
   481  YFICHDQETI KKLFENLRNY DGKNNYPKAC GKFEISAIRD LTTGYDDSQP DKKAVLPTSK
   541  SSQMITFTFA NGGVATMRTS GTEPKIKYYA ELCAPPGNSD PEQLKKELNE LVSAIEEHFF
   601  QPQKYNLQPK AD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

esophagus: 34 nTPM
tonsil: 21 nTPM
urinary bladder: 18 nTPM
retina: 17 nTPM
vagina: 17 nTPM
skin: 17 nTPM

Single-cell type

müller glia: 439 nCPM
esophageal apical cells: 285 nCPM
esophageal suprabasal cells: 194 nCPM
megakaryocytes: 173 nCPM
syncytiotrophoblasts: 121 nCPM
neutrophils: 104 nCPM

Immune cell

eosinophil: 67 nTPM
neutrophil: 34 nTPM
myeloid DC: 32 nTPM
NK-cell: 28 nTPM
classical monocyte: 28 nTPM
intermediate monocyte: 22 nTPM

Brain region

hippocampal formation: 9 nTPM
cerebellum: 8.3 nTPM
cerebral cortex: 8.2 nTPM
choroid plexus: 8.2 nTPM
spinal cord: 6.3 nTPM
white matter: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PGM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSPB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGM2 as an antibody target. Whether an autoantibody or antibody against PGM2 could matter depends on whether native PGM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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