Seroatlas · Human Serome Atlas

HSPBAP1

HSPB1-associated protein 1

Also known as: FLJ22623, HBAP1_HUMAN, PASS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96EW2
Gene
HSPBAP1
Ensembl
ENSG00000169087
Chromosome
3
Canonical length
488 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, although how brain function is affected remains unknown. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q96EW2|HSPBAP1
     1  MAAGSEATTP VIVAAGAGGE EGEHVKPFKP EKAKEIIMSL QQPAIFCNMV FDWPARHWNA
    61  KYLSQVLHGK QIRFRMGMKS MSTVPQFETT CNYVEATLEE FLTWNCDQSS ISGPFRDYDH
   121  SKFWAYADYK YFVSLFEDKT DLFQDVKWSD FGFPGRNGQE STLWIGSLGA HTPCHLDSYG
   181  CNLVFQVQGR KRWHLFPPED TPFLYPTRIP YEESSVFSKI NVVNPDLKRF PQFRKAQRHA
   241  VTLSPGQVLF VPRHWWHYVE SIDPVTVSIN SWIELEEDHL ARVEEAITRM LVCALKTAEN
   301  PQNTRAWLNP TEVEETSHAV NCCYLNAAVS AFFDRCRTSE VVEIQALRTD GEHMKKEELN
   361  VCNHMEVGQT GSQNLTTGTD KPEAASPFGP DLVPVAQRSE EPPSERGGIF GSDGKDFVDK
   421  DGEHFGKLHC AKRQQIMSNS ENAIEEQIAS NTTTTPQTFI STDDLLDCLV NPQVTRIVAQ
   481  LLIQGRSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPBAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 15 nTPM
  • testis: 10 nTPM
  • tongue: 8.1 nTPM
  • spleen: 7 nTPM
  • thymus: 6 nTPM
  • lymph node: 5.8 nTPM

Single-cell type

  • neutrophils: 344 nCPM
  • microglia: 154 nCPM
  • myonuclei: 151 nCPM
  • thymic myoid cells: 110 nCPM
  • syncytiotrophoblasts: 108 nCPM
  • cone photoreceptor cells: 93 nCPM

Immune cell

  • neutrophil: 31 nTPM
  • non-classical monocyte: 24 nTPM
  • basophil: 23 nTPM
  • classical monocyte: 17 nTPM
  • myeloid DC: 13 nTPM
  • intermediate monocyte: 12 nTPM

Brain region

  • choroid plexus: 7.2 nTPM
  • pons: 6.9 nTPM
  • medulla oblongata: 6.7 nTPM
  • cerebral cortex: 6.6 nTPM
  • white matter: 6.6 nTPM
  • hypothalamus: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
1.31
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPBAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPBAP1 as an antibody target. Whether an autoantibody or antibody against HSPBAP1 could matter depends on whether native HSPBAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPBAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPBAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSPBAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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