Seroatlas · Human Serome Atlas

DYDC1

DPY30 domain-containing protein 1

Also known as: bA36D19.5, DPY30D1, DYDC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWB3
Gene: DYDC1
Ensembl: ENSG00000170788
Chromosome: 10
Canonical length: 177 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a member of a family of proteins that contains a DPY30 domain. The encoded protein is involved in acrosome formation during spermatid development. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>Q8WWB3|DYDC1
     1  MESIYLQKHL GACLTQGLAE VARVRPVDPI EYLALWIYKY KENVTMEQLR QKEMAKLERE
    61  RELALMEQEM MERLKAEELL LQQQQLALQL ELEMQEKERQ RIQELQRAQE QLGKEMRMNM
   121  ENLVRNEDIL HSEEATLDSG KTLAEISDRY GAPNLSRVEE LDEPMFSDIA LNIDQDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

testis: 114 nTPM
fallopian tube: 5.3 nTPM
choroid plexus: 1.4 nTPM
epididymis: 1.4 nTPM
lung: 0.9 nTPM
cervix: 0.2 nTPM

Single-cell type

late primary spermatocytes: 809 nCPM
early spermatids: 171 nCPM
early primary spermatocytes: 89 nCPM
late spermatids: 87 nCPM
respiratory ciliated cells: 74 nCPM
fallopian tube ciliated cells: 45 nCPM

Immune cell

basophil: 1.7 nTPM
NK-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

choroid plexus: 4.8 nTPM
midbrain: 1.9 nTPM
spinal cord: 1.7 nTPM
medulla oblongata: 1.3 nTPM
basal ganglia: 1.2 nTPM
hypothalamus: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYDC1 as an antibody target. Whether an autoantibody or antibody against DYDC1 could matter depends on whether native DYDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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